• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >Antisaccade-related brain activation in children with attention-deficit/hyperactivity disorder - A pilot study
【24h】

Antisaccade-related brain activation in children with attention-deficit/hyperactivity disorder - A pilot study

机译：注意缺陷/多动障碍儿童的抗扫视相关脑激活-一项初步研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

While antisaccade paradigms invoke circuitry associated with cognitive control and attention-deficit/hyperactivity disorder (ADHD), there is a dearth of functional magnetic resonance imaging (fMRI) investigations using antisaccade tasks among children with ADHD. Neural correlates associated with antisaccade performance were examined with fMRI in 11 children with ADHD (10 medicated) matched to 11 typically developing children. Significantly greater brain activation in regions in right dorsolateral prefrontal cortex and caudate nucleus was observed in children with ADHD relative to the control group. This pattern separated the children into their respective groups in a taxonomic manner. Sensitivity analyses probing comorbidity and medication-specific effects showed that results were consistent; however, the caudate nucleus difference was only detectable in the full sample, or in subsets with a more relaxed cluster threshold. Antisaccade performance did not significantly differ between the groups, perhaps as a result of greater brain activation or medication effects in the ADHD group. Thus, antisaccade paradigms may have sensitivity and specificity for the investigation of cognitive control deficits and associated neural correlates in ADHD, and may contribute towards the development of new treatment approaches for children with the disorder. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
机译：虽然反扫视范式调用与认知控制和注意力缺陷/多动障碍（ADHD）相关的电路，但缺乏针对患有ADHD的儿童进行反扫视任务的功能磁共振成像（fMRI）研究。用fMRI检查了11名多动症患儿（10名含药者）与11名典型发育中儿童的抗嗅觉表现相关的神经相关性。与对照组相比，ADHD患儿右背外侧前额叶皮层和尾状核区域的大脑激活明显增强。这种模式以分类方式将孩子分为各自的组。探测合并症和药物特效的敏感性分析表明结果是一致的。然而，尾状核差异仅在整个样品中或在具有更宽松簇阈的子集中可检测到。两组之间的抗扫视能力没有显着差异，这可能是由于多动症组大脑激活或药物作用增强所致。因此，抗扫视范式可能对ADHD中认知控制缺陷和相关神经相关性的研究具有敏感性和特异性，并且可能有助于开发针对该疾病儿童的新治疗方法。 （C）2015 Elsevier Ireland Ltd.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号