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Schizoaffective disorder - A possible MEG auditory evoked field biomarker

机译：分裂情感障碍-一种可能的MEG听觉诱发的现场生物标志物

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We recorded magnetoencephalographic auditory steady state responses (SSR) from eight schizoaffective (SAD) subjects and compared the resulting data with previously published findings in persons with schizophrenia (SZ) and controls. SAD subjects exhibited SSR responses similar to controls in the left hemisphere and greater than controls in the right hemisphere, whereas SZ subjects exhibited deficits in both amplitude and phase control in both hemispheres. Our findings suggest preservation of GABAergic inhibitory interneuronal control of layer 3 pyramidal cell activity in primary auditory cortex in SAD.Schizoaffective disorder (SAD), initially described by Kasanin in 1933 (Kasanin, 1933), remains an enigma in terms of how the SAD diagnosis fits into the schizophrenia (SZ)-bipolar spectrum, a situation not well clarified by several recent reviews (Abrams et al, 2008; Cheniaux et al., 2008). In studies of SZ, subjects with SAD are often included in the SZ cohort, suggesting belief in a common pathophysiology. One of the more interesting electrophysiological abnormalities described in SZ is the EEG evoked potential (EP) response to auditory stimuli delivered at a repetition rate of 40 Hz, often termed the steady state response (SSR). Auditory stimulation at 40 Hz entrains the auditory neocortex at the stimulation rate, and the amplitude and phase locking of the resultant EP have both been found to be deficient in SZ (Kwon et al., 1999; Light et al., 2006; Spencer et al., 2008). Recent magnetoencephalography (MEG) studies have suggested the abnormal SSR in SZ is primarily due to impaired phase locking in the left hemisphere, which also results in an apparent amplitude decrement (Teale et al., 2008). We recently recorded MEG responses in the auditory SSR paradigm in a small cohort of SAD subjects, and found differences from results characteristic of SZ. Those results are presented in this report.
机译：我们记录了来自八个精神分裂症（SAD）受试者的磁脑电图听觉稳态反应（SSR），并将所得数据与先前发表的精神分裂症（SZ）和对照患者的发现进行了比较。 SAD受试者的SSR反应与左半球的对照相似，但比右半球的对照大，而SZ受试者的两个半球在幅度和相位控制上均表现出不足。我们的发现表明，在SAD的原发听觉皮层中，第3层锥体细胞活性的GABA抑制性神经节内控制得以保留。最初由Kasanin在1933年（Kasanin，1933年）描述的精神分裂性情感障碍（SAD）对于SAD诊断的方式仍是一个谜。符合精神分裂症（SZ）-双极谱，最近的一些评论并没有很好地阐明这种情况（Abrams等，2008; Cheniaux等，2008）。在SZ的研究中，SAD受试者通常被包括在SZ队列中，这表明人们对共同的病理生理学抱有信念。 SZ中描述的更有趣的电生理异常之一是对以40 Hz重复频率传递的听觉刺激的EEG诱发电位（EP）反应，通常称为稳态反应（SSR）。 40 Hz的听觉刺激会以刺激速率夹带听觉新皮层，并且已发现合成EP的幅度和相位锁定均缺乏SZ（Kwon等人，1999; Light等人，2006; Spencer等人）等（2008）。最近的脑磁图（MEG）研究表明，SZ中的SSR异常主要是由于左半球的相位锁定受损，这也导致振幅明显下降（Teale等，2008）。我们最近在一小群SAD受试者的听觉SSR范例中记录了MEG反应，发现与SZ的特征性结果存在差异。这些结果显示在本报告中。

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