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首页> 外文期刊>Psychiatry Research. Neuroimaging >Default-mode network connectivity and white matter burden in late-life depression
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Default-mode network connectivity and white matter burden in late-life depression

机译：晚期抑郁症中的默认模式网络连接和白质负担

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The brain's default-mode network has been the focus of intense research. This study characterizes the default-mode network activity in late-life depression and the correlation of the default-mode network activity changes with the white-matter hyperintensities burden. We hypothesized that elderly depressed subjects would have altered default-mode network activity, which would correlate with the increased white-matter hyperintensities burden. Twelve depressed subjects (mean Hamilton Depression Rating Scale 19.8 ± 4.1, mean age 70.5 ± 4.9) and 12 non-depressed, comparison subjects (mean age 69 ± 6.5) were included. Functional magnetic resonance imaging (fMRI) data were collected while subjects performed a low cognitive load, event-related task. We compared the default-mode network activity in these groups (including depressed subjects pre- and post-antidepressant treatment). We analyzed the resting connectivity patterns of the posterior cingulate cortex. Deconvolution was used to evaluate the correlation of resting-state connectivity scores with the white-matter hyperintensities burden. Compared with non-depressed elderly, depressed subjects pretreatment had decreased connectivity in the subgenual anterior cingulate cortex and increased connectivity in the dorsomedial prefrontal cortex and the orbito-frontal cortex. The abnormal connectivity was significantly correlated with the white-matter hyperintensities burden. Remitted elderly depressed subjects had improved functional connectivity compared to pretreatment, although alterations persisted in the anterior cingulate and the prefrontal cortex when remitted elderly depressed subjects were compared with non-depressed elderly. Our study provides evidence for altered default-mode network connectivity in late-life depression. The correlation between white-matter hyperintensities burden and default-mode network connectivity emphasizes the role of vascular changes in late-life depression etiopathogenesis.
机译：大脑的默认模式网络一直是深入研究的重点。这项研究的特点是在晚期抑郁症中的默认模式网络活动和默认模式网络活动的变化与白质高强度负担的相关性。我们假设老年人抑郁的受试者会改变默认模式的网络活动，这与增加的白质高强度负担相关。包括十二名抑郁受试者（平均汉密尔顿抑郁量表19.8±4.1，平均年龄70.5±4.9）和十二名非抑郁对照受试者（平均年龄69±6.5）。在受试者执行低认知负荷，事件相关任务时，收集功能磁共振成像（fMRI）数据。我们比较了这些组中的默认模式网络活动（包括抑郁症患者的抗抑郁药治疗前后）。我们分析了后扣带回皮层的休息连接模式。反卷积用于评估静止状态连接性得分与白质高强度负担的相关性。与未抑郁的老年人相比，抑郁的受试者的预处理在扣带下前扣带皮层的连通性降低，在背囊前额叶皮层和眶额皮质中的连通性增加。异常的连通性与白质过度紧张负担显着相关。与接受治疗的老年抑郁症患者相比，接受治疗的老年抑郁症患者与未抑郁的老年患者相比，功能连接性比预处理有所改善，尽管前扣带和前额叶皮层的改变仍然存在。我们的研究为晚期抑郁症患者改变默认模式网络连接提供了证据。白质高信号负担与默认模式网络连通性之间的相关性强调了血管变化在晚期抑郁症发病机制中的作用。

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