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首页> 外文期刊>Psychiatry Research. Neuroimaging >Hypo-activation in the executive core of the sustained attention network in adolescent offspring of schizophrenia patients mediated by premorbid functional deficits.
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Hypo-activation in the executive core of the sustained attention network in adolescent offspring of schizophrenia patients mediated by premorbid functional deficits.

机译：病态前功能缺陷介导的精神分裂症患者青春期后代持续关注网络执行核心的功能低下激活。

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Adolescent offspring of schizophrenia patients (SCZ-Off) are vulnerable to psychiatric disorders. Assessing relationships between clinical and biological measures (such as functional magnetic resonance imaging, fMRI) may elucidate pathways of vulnerability in this group. Here we assessed the relationship between clinically assessed premorbid function, and cortico-striatal activity during sustained attention in controls (HC: with no family history of psychosis) and SCZ-Off. Subjects (n=39) were assessed using the Structured Interview for Prodromal Syndromes and the Scale of Prodromal Symptoms. Based on the Global Assessment of Functioning (GAF) score, SCZ-Off were cleaved into "high" or "low" clinically functioning sub-groups (SCZ-Off(HF), SCZ-Off(LF) respectively). During fMRI, subjects participated in a modified continuous performance task (CPT-IP). fMRI was conducted on a Bruker MedSpec 4T system (345 EPI scans; TR=2s; 24 slices; 3.8x3.8x4mm). Results show SCZ-Off(LF) evinced less activation than both HC and SCZ-Off(HF) in the executive core of the brain's attentional system (anterior cingulate, dorsal prefrontal cortex and caudate), but not visuo-spatial regions such as primary visual or superior parietal cortex. Differences were independent of behavioral performance, and reduction in activity was related to GAF score in a dose-dependent manner. Assessing the relationship between clinical measures and brain activity in domains such as attention provides a window into mechanisms of vulnerability in the developing adolescent brain.
机译：精神分裂症患者的青少年后代（SCZ-Off）易患精神病。评估临床和生物学指标（例如功能性磁共振成像，fMRI）之间的关系可以阐明该人群的易感性途径。在这里，我们评估了持续评估的对照组（HC：无精神病家族史）和SCZ-Off期间临床评估的病前功能与皮质纹状体活动之间的关系。使用前驱综合征的结构化访谈和前驱症状量表对受试者（n = 39）进行评估。根据整体功能评估（GAF）评分，将SCZ-Off分为“高”或“低”临床功能亚组（分别为SCZ-Off（HF），SCZ-Off（LF））。在功能磁共振成像期间，受试者参加了一项修改后的持续表现任务（CPT-IP）。在Bruker MedSpec 4T系统上进行功能磁共振成像（345 EPI扫描; TR = 2s; 24片; 3.8x3.8x4mm）。结果显示，SCZ-Off（LF）在大脑注意力系统执行核心（前扣带回，前额叶皮层和尾状）的执行核心中的激活少于HC和SCZ-Off（HF），但在视觉空间区域（例如原发性）中却没有视觉或顶叶上皮。差异与行为表现无关，并且活动减少与GAF得分呈剂量依赖性。在诸如注意力之类的领域中评估临床措施与大脑活动之间的关系，为了解青少年大脑发育中的脆弱性机制提供了一个窗口。

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