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首页> 外文期刊>Psychiatry Research. Neuroimaging >Cerebellar and lobar blood flow in schizophrenia: a perfusion weighted imaging study.
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Cerebellar and lobar blood flow in schizophrenia: a perfusion weighted imaging study.

机译：精神分裂症的小脑和大叶血流：灌注加权成像研究。

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摘要

It is still not clear whether brain hemodynamics plays a role in the functional and structural alterations in schizophrenia, since prior imaging studies showed conflicting findings. In this study we non-invasively explored cerebral and cerebellar lobe perfusion in the largest population of participants with schizophrenia thus far studied with perfusion-weighted imaging (PWI). Forty-seven participants affected by schizophrenia and 29 normal controls were recruited. PWI images were acquired following the intravenous injection of a paramagnetic contrast agent. Regional cerebral blood volume (CBV), blood flow (rCBF), and mean transit time (MTT) were obtained with the block-Circulant Singular Value Decomposition (cSVD) for frontal, temporal, parietal, occipital, and cerebellar lobes, bilaterally. Perfusion parameters were separately obtained for both gray and white matter in each lobe. Subjects with schizophrenia showed no significant differences in perfusion parameters when compared with controls. Interestingly, inverse correlations between age at onset and occipital, frontal and cerebellar MTT and between length of illness and frontal CBV were found. Preserved cerebral and cerebellar perfusion in our chronic population may in part be due to the effects of antipsychotic treatment which may have normalized blood volume and flow. Hypoperfusion in relation to chronicity, particularly in the frontal lobe, has been observed in accordance with earlier studies using positron emission tomography.
机译：尚不清楚脑血流动力学是否在精神分裂症的功能和结构改变中起作用，因为先前的影像学研究显示矛盾的发现。在这项研究中，我们以灌注加权成像（PWI）进行了无创性研究，探讨了迄今为止最大的精神分裂症患者人群的脑和小脑叶灌注。招募了47位受精神分裂症影响的参与者和29位正常对照。静脉注射顺磁性造影剂后获得PWI图像。分别通过额叶，颞叶，顶叶，枕叶和小脑叶的块循环奇异值分解（cSVD）来获得双侧的局部脑血容量（CBV），血流量（rCBF）和平均通过时间（MTT）。分别获得每个叶中灰质和白质的灌注参数。与对照组相比，精神分裂症患者的灌注参数无明显差异。有趣的是，发现发病年龄与枕骨，额叶和小脑MTT之间的负相关，以及病程和额叶CBV之间的负相关。在我们的慢性人群中保留的脑和小脑灌注可能部分归因于抗精神病药物治疗的作用，这可能使血容量和血流量正常化。根据早期使用正电子发射断层扫描的研究，已经观察到与慢性有关的灌注不足，特别是在额叶。

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