• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >In vivo evidence of global and focal brain alterations in anorexia nervosa.
【24h】

In vivo evidence of global and focal brain alterations in anorexia nervosa.

机译：神经性厌食症的全局和局部大脑改变的体内证据。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Brain alterations are known to be associated with anorexia nervosa (AN) and tend to be distributed across brain structures, with only a few reports describing focal damage. Magnetic resonance images of 21 anorexic patients with different disease duration and 27 control subjects were acquired and compared using voxel-based morphometry (VBM). Patients had a significant reduction of total white matter (WM) volume and focal gray matter (GM) atrophy in cerebellum, hypothalamus, caudate nucleus and frontal, parietal and temporal areas. The cerebellum was more affected in patients with longer disease duration, whereas the hypothalamic alterations were more pronounced in patients with shorter food restriction. A correlation with body mass index (BMI) and GM was found in the hypothalamus. Our data demonstrate a diffuse reduction of WM together with focal areas of GM atrophy in AN. The finding of a hypothalamic focal atrophy points to hormonal dysfunction and opens the possibility for a central dysregulation of homeostasis. The involvement of temporoparietal areas could account for body image distortion. Finally, the cerebellar GM atrophy confirms previous findings and seems to be a late consequence of AN that could play a role in the chronic phase of the disease.
机译：已知大脑改变与神经性厌食症（AN）有关，并且倾向于分布在整个大脑结构中，只有少数报道描述了局灶性损伤。使用基于体素的形态计量学（VBM），获取并比较了21名不同疾病持续时间的厌食症患者和27名对照受试者的磁共振图像。患者的小脑，下丘脑，尾状核以及额叶，顶叶和颞叶区域的总白质（WM）体积和局灶性灰质（GM）萎缩明显减少。病程较长的患者小脑受到的影响更大，而禁食时间较短的患者的下丘脑改变更为明显。下丘脑中发现与体重指数（BMI）和GM相关。我们的数据表明WM的弥漫性减少以及AN中GM萎缩的病灶区域。下丘脑局灶性萎缩的发现表明荷尔蒙功能障碍，并为体内稳态失调提供了可能。颞顶区的累及可以解释人体图像失真。最后，小脑GM萎缩证实了先前的发现，似乎是AN的晚期后果，可能在疾病的慢性期发挥作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号