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首页> 外文期刊>Psychiatry Research. Neuroimaging >Duloxetine's modest short-term influences in subcortical structures of first episode drug-na?ve patients with major depressive disorder and panic disorder
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Duloxetine's modest short-term influences in subcortical structures of first episode drug-na?ve patients with major depressive disorder and panic disorder

机译：度洛西汀对初次患有轻度抑郁症和恐慌症的首次药物初治患者皮质下结构的短期影响

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We developed this study to follow up the hanges in subcortical structures after 6 weeks' treatment with therapy of duloxetine in first episode drug-na?ve patients with major depressive disorder and panic disorder. Fifteen patients received duloxetine 60 mg/d therapy for 6 weeks and achieved remission. They all underwent structural magnetic resonance imaging (MRI) of the brain at baseline and week 6. Fifteen healthy controls were also scanned twice at baseline and week 6 to exclude possible biases. Structural MRI data were preprocessed with FMRIB's Integrated Registration and Segmentation Tool function (FIRST version 1.2) of FSL (FMRIB Software Library; version 4.1.1) to perform subcortical segmentations of the brain using a shape and appearance model. Nonparametric corrections of these structural volumes in an F-test between pre- and post-treatment were used to identify the changes after duloxetine therapy. A false discovery correction of the F-test by FIRST was also performed. A paired t-test using SPSS was applied to confirm the changes in these structures. The patients had consistent changes of volumes in bilateral nucleus accumbens, left putamen, left hippocampus and brainstem after 6 weeks of treatment with duloxetine. There were no consistent changes in other subcortical structures. There were modest increases of the volumes of the above areas, which were not significant after false discovery correction by FIRST F-test comparisons. The volumetric increases were correlated with responses of clinical symptoms. The results suggested that duloxetine possibly contributed to modest increases in several subcortical areas of these patients with remission.
机译：我们开展了这项研究，以追踪度洛西汀治疗首发，初治，重度抑郁症和恐慌症患者的6周治疗后皮质下结构的垂线。 15名患者接受度洛西汀60 mg / d治疗6周，并获得缓解。他们都在基线和第6周对大脑进行了结构磁共振成像（MRI）。在基线和第6周，还对15名健康对照进行了两次扫描，以排除可能的偏倚。使用FSL的FMRIB的集成配准和分割工具功能（FIRST 1.2版）（FMRIB软件库; 4.1.1版）对结构MRI数据进行预处理，以使用形状和外观模型对大脑进行皮层下分割。在治疗前和治疗后的F检验中对这些结构体积的非参数校正用于确定度洛西汀治疗后的变化。还执行了FIRST对F检验的错误发现校正。使用SPSS进行配对t检验以确认这些结构的变化。用度洛西汀治疗6周后，患者双侧伏隔核，左壳核，左海马体和脑干的体积持续变化。其他皮层下结构没有一致的变化。上述区域的体积适度增加，在通过FIRST F-test比较进行错误发现校正后，这并不显着。体积增加与临床症状的反应相关。结果表明，度洛西汀可能有助于缓解这些患者的几个皮层下区域。

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