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首页> 外文期刊>Psychiatry Research. Neuroimaging >Excessive contralateral motor overflow in schizophrenia measured by fMRI
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Excessive contralateral motor overflow in schizophrenia measured by fMRI

机译：功能磁共振成像测量精神分裂症对侧运动过度

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Schizophrenia is characterized by significant problems in control of behavior; however, the disturbances in neural systems that control movement remain poorly characterized. We used functional magnetic resonance imaging (fMRI) to evaluate the origin of motor overflow in schizophrenia. Twenty-seven clinically stable medicated outpatients with Diagnostic and Statistical Manual, 4th edition, text revision (DSM-IV-TR)-defined schizophrenia (SZ), and 18 healthy control (HC) subjects, all right-handed, performed a dominant-handed, single-choice visual sensorimotor reaction time paradigm during fMRI. Voxel-wise analyses were conducted within sensorimotor cortical and striatal regions on general linear model (GLM)-derived measures of blood oxygen level-dependent (BOLD) signal change. The SZ group was not different from the HC group in reaction time, activation in somatosensory or motor cortices ipsilateral to the active (intended) descending corticospinal tract, nor visual cortex. However, in the right hemisphere (contralateral to the active M1), the SZ group showed significantly higher activation in primary motor cortex and adjacent premotor and somatosensory cortices (right Brodmann areas (BA) 1 through 4, and 6), and significantly lower activation in bilateral basal ganglia. Right BA 4 activation was strongly related to disorganization and poverty symptoms (and unrelated to medications) in the patient group. This study provides evidence in SZ of excessive neural activity in motor cortex contralateral to the intended primary motor cortex, which may form the basis for altered motor laterality and motor overflow previously observed, and disorganized behavior. This pathological motor overflow may be partly due to altered modulation of intended movement within the basal ganglia and premotor cortex.
机译：精神分裂症的特征在于行为控制方面的重大问题。但是，控制运动的神经系统中的干扰仍然很难被描述。我们使用功能性磁共振成像（fMRI）来评估精神分裂症中马达溢流的起源。 27名临床稳定的药物门诊患者，诊断和统计手册，第4版，文本修订版（DSM-IV-TR）定义的精神分裂症（SZ），以及18位健康对照（HC）受试者，都是惯用右手的， fMRI期间进行的单手选择视觉视觉运动反应时间范例。在感觉运动皮层和纹状体区域内进行体素分析，使用一般线性模型（GLM）得出的血氧水平依赖性（BOLD）信号变化量度。 SZ组与HC组在反应时间，在活动的（预期的）皮质脊髓下降道同侧的体感或运动皮层中的激活，视觉皮层方面无差异。但是，在右半球（与活动M1对侧），SZ组在初级运动皮层和邻近的运动前和体感皮层（右Brodmann区域（BA）1至4和6）显示出明显更高的激活，而其激活明显降低在双侧基底神经节。右BA 4的激活与患者组的紊乱和贫困症状（与药物无关）密切相关。这项研究在SZ中提供了与预期的原发性运动皮层相反的运动皮层过度神经活动的证据，这可能为先前观察到的改变运动侧性和运动性溢出以及行为混乱提供了基础。这种病理性运动溢出可能部分归因于基底神经节和运动前皮层内预期运动的调制改变。

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