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首页> 外文期刊>Psychiatry Research. Neuroimaging >Abnormal functional motor lateralization in healthy siblings of patients with schizophrenia
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Abnormal functional motor lateralization in healthy siblings of patients with schizophrenia

机译：精神分裂症患者健康兄弟姐妹的异常功能性运动偏侧化

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摘要

Earlier neuroimaging studies of motor function in schizophrenia have demonstrated reduced functional lateralization in the motor network during motor tasks. Here, we used event-related functional magnetic resonance imaging during a visually guided motor task in 18 clinically unaffected siblings of patients with schizophrenia and 24 matched controls to investigate if abnormal functional lateralization is related to genetic risk for this brain disorder. Whereas activity associated with motor task performance was mainly contralateral with only a marginal ipsilateral component in healthy participants, unaffected siblings had strong bilateral activity with significantly greater response in ipsilateral and contralateral premotor areas as well as in contralateral subcortical motor regions relative to controls. Reduced lateralization in siblings was also identified with a measure of laterality quotient. These findings suggest that abnormal functional lateralization of motor circuitry is related to genetic risk of schizophrenia.
机译：较早的精神分裂症运动功能的神经影像学研究表明，在运动任务期间，运动网络中的功能偏侧化程度降低。在这里，我们在18位临床未受影响的精神分裂症患者兄弟姐妹和24位相匹配的对照患者的视觉指导的运动任务中，使用了事件相关的功能磁共振成像，以研究异常的功能偏侧性是否与该脑部疾病的遗传风险相关。在健康参与者中，与运动任务执行相关的活动主要是对侧活动，而同侧边缘仅是边缘，而未受影响的兄弟姐妹则具有较强的双侧活动，同侧和对侧运动前区域以及对侧皮层下运动区域的反应明显高于对照组。兄弟姐妹的偏侧化程度的降低也可以通过偏侧商度来确定。这些发现表明，运动电路的异常功能侧化与精神分裂症的遗传风险有关。

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