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首页> 外文期刊>Psychiatry Research. Neuroimaging >Confirmation of MRI anatomical measurements as endophenotypic markers for bipolar disorder in a new sample from the NIMH Genetics of Bipolar Disorder in Latino Populations study
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Confirmation of MRI anatomical measurements as endophenotypic markers for bipolar disorder in a new sample from the NIMH Genetics of Bipolar Disorder in Latino Populations study

机译：从拉丁裔人群双相情感障碍的NIMH遗传学新样本中确认MRI解剖学测量为双相情感障碍的内表型标记

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The main objective of this study is to establish potential neuromorphometric differences which might act as markers of genetic risk for bipolar disorder and therefore serve as endophenotypes for discovery of genes that contribute to bipolar disorder. Magnetic resonance imaging (MRI) was used to assess structural brain volumes of 49 subjects. Volumetric analyses were first performed to test possible differences in the volume of brain structures between subjects with bipolar disorder type I (BPI) and control subjects in a new sample, based on regions previously reported in the literature as being either increased or decreased in size in bipolar patients. Subsequently, for those brain regions showing statistical difference between subjects with BPI and control subjects in our new sample, we tested whether unaffected first degree relatives (UFRs) of the BPI subjects also showed similar differences compared with controls. Four specific regions (right prefrontal, right middle prefrontal, right globus pallidus and left globus pallidus) met criteria for being possible endophenotypes for BPI in this sample. (C) 2015 The Authors. Published by Elsevier Ireland Ltd.
机译：这项研究的主要目的是建立潜在的神经形态学差异，这些差异可能是双相情感障碍遗传风险的标志，因此可以作为内表型来发现有助于双相情感障碍的基因。磁共振成像（MRI）用于评估49位受试者的大脑结构。首先根据新文献中先前报道的区域大小增加或减少，对新样本中患有I型躁郁症（BPI）的受试者与对照受试者之间的大脑结构的体积差异进行测试。双相患者。随后，对于那些在我们的新样本中显示BPI受试者与对照受试者之间的统计差异的大脑区域，我们测试了BPI受试者的未受影响的一级亲属（UFR）是否也显示出与对照组相似的差异。四个特定区域（右前额叶，右中前额叶，右苍白球和左苍白球）符合此样品中BPI可能的内表型标准。 （C）2015作者。由Elsevier Ireland Ltd.发布

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