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Color Stroop and negative priming in schizophrenia: An fMRI study

机译:功能性磁共振成像研究:精神分裂症患者的颜色Stroop和阴性引发

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摘要

Disturbances in selective attention represent a core characteristic of schizophrenia, whose neural underpinnings have yet to be fully elucidated. Consequently, we recorded brain activation using functional magnetic resonance imaging (fMRI) while 15 patients with schizophrenia and 15 age-matched controls performed a well-established measure of selective attention-the color Stroop negative priming task. We focused on two aspects of performance: overriding pre-potent responses (Stroop effect) and inhibition of prior negatively primed trials (negative priming effect). Behaviorally, controls demonstrated both significant Stroop and negative priming effects, while schizophrenic subjects only showed the Stroop effect. For the Stroop effect, fMRI indicated significantly greater activation in frontal regions-medial frontal gyrus/anterior cingulate gyrus and middle frontal gyrus for controls-but greater activation in medial parietal regions (posterior cingulate gyrus/precuneus) for patients. Negative priming elicited significant activation in right dorsolateral prefrontal cortex for both groups, but also in left dorsolateral prefrontal cortex for patients. These different patterns of fMRI activation may reflect faulty interaction in schizophrenia within networks of brain regions that are vital to selective attention.
机译:选择性注意力障碍是精神分裂症的核心特征,其神经基础尚未完全阐明。因此,我们使用功能磁共振成像(fMRI)记录了大脑的激活情况,而15例精神分裂症患者和15例年龄相匹配的对照者则进行了一种公认的选择性注意力测量方法-彩色Stroop负引物任务。我们专注于性能的两个方面:超越潜在的反应(Stroop效应)和抑制先前的阴性引发试验(阴性引发效应)。在行为上,对照既显示出显着的Stroop效应又显示出负面的启动效应,而精神分裂症受试者仅显示出Stroop效应。对于Stroop效应,功能磁共振成像显示在额叶区域的激活显着增强-额叶内侧回/前扣带回和中额叶回作为对照,但患者的额壁内侧区域(后扣带回/前突神经)的激活更大。负启动引发两组的右背外侧前额叶皮层均显着激活,患者也可在左侧背外侧前额叶皮层中显着激活。 fMRI激活的这些不同模式可能反映出对选择性注意至关重要的大脑区域网络内的精神分裂症相互作用不良。

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