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首页> 外文期刊>Psychiatry Research. Neuroimaging >Short-TE proton magnetic resonance spectroscopy investigation in adolescents with attention-deficit hyperactivity disorder
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Short-TE proton magnetic resonance spectroscopy investigation in adolescents with attention-deficit hyperactivity disorder

机译：注意缺陷多动障碍青少年的短TE质子磁共振波谱研究

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摘要

In this study, short echo time ^-magnetic resonance spectroscopy (MRS) was applied for quantification of neurometabolites using the LC Model algorithm in Taiwanese adolescents with attention-deficit hyperactivity disorder (ADHD). Proton magnetic resonance spectra were acquired bilaterally on the prefrontal area (part of the anterior cingulate gyrus and part of the medial frontal gyrus) in 15 adolescents with ADHD (average age of 13.88 years) and 22 controls (average age of 14.85 years). Absolute metabolite levels and ratios relative to creatine plus phosphocreatine (Cr + PCr) were obtained to be compared between groups. Results showed that adolescents with ADHD had significantly lower mean right prefrontal levels of Cr+PCr as compared with the controls. No significant differences between groups were noted in the remainder of the prefrontal metabolites. As for the group comparison of relative ratios, the N-acetylaspartate/Cr + PCr ratio was significantly higher in the right prefrontal regions of ADHD adolescents. This finding provides evidence of a right prefrontal neurochemical alteration in ADHD adolescents, which is consistent with current ADHD theory of prefrontal neuropathology with developmental mechanism. In addition, it highlights the importance of the method in interpretation of MRS findings in the context of ADHD.
机译：在这项研究中，短时回声时间磁共振波谱法（MRS）被应用在LC模型算法对台湾患有注意力缺陷多动障碍（ADHD）的青少年中的神经代谢物进行定量。在15名ADHD（平均年龄为13.88岁）和22名对照（平均年龄为14.85岁）的青少年的前额区域（前扣带回的一部分和额额内侧的一部分）的双侧获取质子磁共振波谱。获得相对于肌酸和磷酸肌酸（Cr + PCr）的绝对代谢物水平和比例，以在组之间进行比较。结果显示，与对照组相比，患有ADHD的青少年的平均右前额叶Cr + PCr水平明显降低。在其余的前额叶代谢产物中，各组之间没有显着差异。至于相对比例的组比较，在ADHD青少年的右前额叶区域，N-乙酰天门冬氨酸/ Cr + PCr比明显更高。该发现提供了在ADHD青少年中右前额叶神经化学改变的证据，这与当前具有发展机制的前额叶神经病理学的ADHD理论是一致的。此外，它突出了该方法在多动症背景下解释MRS结果的重要性。

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