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首页> 外文期刊>Psychiatry Research. Neuroimaging >The prefrontal cortex influence over subcortical and limbic regions governs antidepressant response by N=H/(M+R)
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The prefrontal cortex influence over subcortical and limbic regions governs antidepressant response by N=H/(M+R)

机译：前额叶皮质对皮质下和边缘区的影响决定了抗抑郁反应的作用是N = H /（M + R）

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We review the evidence for relationships between metabolic activity of cortical, subcortical and limbic brain regions in depression and the efficacy of antidepressant agents. The influence of these regions can be described by an algebraic equation, N=H/(M+R), where N represents a homeostatic level of executive function, H represents prefrontal (Brodmann areas 9, 10, 11, 12; 46) and cingulate cortex activity (24, 25; 32), M represents subcortical (hippocampus, parahippocampal gyrus) influences, and R represents limbic (amygdala) influences. This hypothesis is based on depressed prefrontal cortex and enhanced amygdala and hippocampal metabolism in major depressive disorder, and the remission of these changes by most antidepressant interventions. The therapeutic efficacy of antidepressant strategies may depend less on their presumptive molecular mechanisms of action and more on their ability to restore the predominant metabolic and executive functions of the prefrontal cortex, and dampen excessive subcortical and limbic influences.
机译：我们审查了在抑郁症中皮质，皮质下和边缘脑区的代谢活性与抗抑郁药功效之间关系的证据。这些区域的影响可以用代数方程N = H /（M + R）来描述，其中N表示执行功能的稳态水平，H表示前额叶（Brodmann区域9、10、11、12; 46）和扣带回皮质活动（24，25; 32），M代表皮质下（海马，海马旁回）影响，R代表边缘（杏仁核）影响。该假设基于严重抑郁症中前额叶皮层的凹陷以及杏仁核和海马代谢的增强，以及大多数抗抑郁干预措施可缓解这些变化。抗抑郁策略的治疗效果可能较少取决于其推测的分子作用机制，而更多取决于其恢复前额叶皮层的主要代谢和执行功能，并抑制皮质和边缘下过多影响的能力。

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