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首页> 外文期刊>Psychiatry Research. Neuroimaging >Symptom Attribution in first episode psychosis: A cortical thickness study
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Symptom Attribution in first episode psychosis: A cortical thickness study

机译：首发精神病的症状归因：皮质厚度研究

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One dimension of insight in psychosis is the ability to attribute correctly one's symptoms to a mental disorder. Recent work suggests that gray matter volumes of the orbitofrontal cortex (OFC) are correlated with aggregate symptom attribution scores in first-episode schizophrenia. Whether regions beyond the OFC are important for symptom attribution remains to be established. Further, whether common or separable neural systems underlie attribution of specific symptoms (e.g., delusions, asociality) has not been studied. In the current magnetic resonance imaging study, 52 people with a first-episode psychosis (FEP) were rated with the Scale for Assessment of Unawareness of Mental Disorder on attribution of hallucinations, delusions, flat affect and asociality. Attribution ratings were regressed on cortical thickness at 81,924 vertices. Mapping statistics revealed that delusion misattribution was associated with thickness in the OFC [Brodmann's area (BA) 11/47]. Delusion, flat affect and asociality misattribution were associated with cortical thinness in the dorsolateral prefrontal cortex (BA 9/46). Differential associations emerged between each attribution item and cortical thickness/thinness in a variety of frontal, temporal, parietal and occipital areas. The results imply a selective role for the OFC in delusion misattribution in FEP. Evidence for cortical thickness covariation in a variety of regions suggests partial independence in the neural architecture underlying attribution for different symptoms in FEP.
机译：精神病洞察力的一个方面是能够将自己的症状正确归因于精神障碍。最近的工作表明，眶额叶皮层（OFC）的灰质体积与首发精神分裂症的总体症状归因评分相关。 OFC以外的区域对于症状归因是否重要还有待确定。此外，尚未研究普通或可分离的神经系统是特定症状（例如妄想，协会）的基础。在当前的磁共振成像研究中，对52名初发性精神病（FEP）的人进行了幻觉归因，妄想，妄想，扁平情感和社交的评定量表。归因等级针对81,924个顶点的皮质厚度进行了回归。测绘统计数据表明，妄想错配与OFC的厚度有关[Brodmann's Area（BA）11/47]。妄想，扁平化的情感和社团的错误归因与背外侧前额叶皮层的皮质变薄有关（BA 9/46）。在各个额叶，颞叶，顶叶和枕叶区域，每个归因项与皮质厚度/厚度之间都存在差异关联。结果暗示OFC在FEP中的错觉错配中具有选择性作用。在不同区域的皮层厚度协变的证据表明，FEP中不同症状归因于神经结构的部分独立性。

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