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Feedback processing in schizophrenia: Effects of affective value and remedial action

机译：精神分裂症的反馈处理：情感价值和补救措施的影响

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摘要

Error-monitoring deficits in schizophrenia have been found, but results with respect to feedback processing and remedial action were unclear. The present study examined the role of emotion in feedback processing in medication-free patients with recent-onset schizophrenia. Patients and controls performed a time-estimation task, and brain activation was measured with functional magnetic resonance imaging (fMRI). Participants had to estimate a 1-s interval and received feedback about their performance in the form of words or facial expressions. Patients performed the task at the same level as the controls and used the feedback to improve performance. Brain activation following the feedback stimuli in the rostral cingulate zone differed between groups, but this effect depended on the modality of the feedback stimulus. Patients showed a differential response to verbal and facial feedback in the rostral cingulate zone, whereas healthy controls did not differ between modalities. Furthermore, activation in the rostral cingulate zone following facial feedback was negatively related to severity of the disease as expressed by the scores on positive symptom subscale of the Positive and Negative Syndrome Scale. Both findings point in the direction of a specific deficit in patients which is related to the emotional impact of external feedback.
机译：已经发现精神分裂症的错误监测缺陷，但是关于反馈处理和补救措施的结果尚不清楚。本研究检查了情绪在新发精神分裂症的无药物患者反馈处理中的作用。患者和对照组执行时间估算任务，并通过功能性磁共振成像（fMRI）测量大脑的活动。参与者必须估计一个1秒的间隔，并以言语或面部表情的形式接收有关其表现的反馈。患者以与对照相同的水平执行任务，并使用反馈来改善表现。各组在鼻扣带回带中的反馈刺激后的大脑激活情况不同，但是这种效果取决于反馈刺激的方式。患者在有喙扣带区域对口头和面部反馈表现出不同的反应，而健康对照在两种方式之间没有差异。此外，面部和面部反馈后的延髓带状扣带区的激活与疾病的严重程度负相关，如阳性和阴性综合征量表的阳性症状子量表上的得分所表示。两项发现均指向患者特定缺陷的方向，该缺陷与外部反馈的情感影响有关。

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