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Complex chimerism:Pregnancy after solid organ transplantation

机译：复杂嵌合体：实体器官移植后的怀孕

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Thousands of women with organ transplantation have undergone successful pregnancies, however little is known about how the profound immunologic changes associated with pregnancy might influence tolerance or rejection of the allograft. Pregnant women with a solid organ transplant are complex chimeras with multiple foreign cell populations from the donor organ, fetus, and mother of the pregnant woman. We consider the impact of complex chimerism and pregnancy-associated immunologic changes on toleranceof the allograft both during pregnancy and the postpartum period. Mechanisms of allograft tolerance are likely dynamic during pregnancy and affected by the influx of fetal microchimeric cells, HLA relationships (between the fetus, pregnant woman and/or donor), peripheral T cell tolerance to fetal cells, and fetal minor histocompatibility antigens. Further research is necessary to understand the complex immunology during pregnancy and the postpartum period of women with a solid organ transplant.
机译：成千上万的接受器官移植的妇女已经成功怀孕，但是与怀孕相关的深刻免疫学变化如何影响同种异体移植的耐受性或排斥性知之甚少。具有实体器官移植的孕妇是复杂的嵌合体，具有来自供体器官，胎儿和孕妇母亲的多个外来细胞。我们考虑复杂的嵌合体和妊娠相关的免疫学变化对同种异体移植物在妊娠期间和产后耐受性的影响。同种异体移植耐受的机制可能在怀孕期间是动态的，并受胎儿微嵌合细胞的涌入，HLA关系（在胎儿，孕妇和/或供体之间），对胎儿细胞的外周T细胞耐受以及胎儿次要组织相容性抗原的影响。有必要进行进一步的研究，以了解妊娠和实体器官移植妇女产后的复杂免疫学。

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