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首页> 外文期刊>Chimerism >Maternal microchimerism in biliary atresia Are maternal cells effector cells, targets, or just bystanders?
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Maternal microchimerism in biliary atresia Are maternal cells effector cells, targets, or just bystanders?

机译：胆道闭锁的母体微嵌合体母体细胞是效应细胞，靶标还是旁观者？

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摘要

The etiology of biliary atresia (BA) is unknown; however, the liver histology is similar to that observed in immune-mediated hepatic disorders. Liver fibrosis in BA progresses even after bile drainage has been achieved by the Kasai operation. Maternalmicrochimerism has been purported to play a part in the pathogenesis of BA as well as certain autoimmune diseases. However, the role of maternal cells has not yet been determined in BA. Specifically, it is unknown whether these maternal cells function as maternal effector T lymphocytes, or targets or bystanders. We currently hypothesize that the first hit is due to GvHD interaction by engrafted maternal effector T lymphocytes. Furthermore, we suggest that the secondary effects that are manifested by progressive cirrhosis are caused either by maternal chimeric effector T lymphocytes (e.g., GvHD interaction) or targets (e.g., HvGD interaction). Based on our hypothesis, mixed lymphocyte reactions between patients and their mothers might shed light on theetiopathogenesis and prognostic indicators.
机译：胆道闭锁的病因尚不清楚。但是，肝脏的组织学与免疫介导的肝病相似。即使通过Kasai手术实现了胆汁引流，BA中的肝纤维化仍在进展。母体微嵌合体据称在BA以及某些自身免疫性疾病的发病机理中起作用。但是，BA中尚未确定母体细胞的作用。具体而言，尚不清楚这些母体细胞是作为母体效应T淋巴细胞，还是靶标或旁观者。我们目前假设，第一击是由于嫁接的母体效应T淋巴细胞与GvHD相互作用。此外，我们建议由进行性肝硬化表现出的继发效应是由母体嵌合效应T淋巴细胞（例如，GvHD相互作用）或靶标（例如，HvGD相互作用）引起的。根据我们的假设，患者及其母亲之间的混合淋巴细胞反应可能会揭示出其发病机理和预后指标。

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