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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Association between depression and elevated C-reactive protein.
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Association between depression and elevated C-reactive protein.

机译：抑郁症与C反应蛋白升高之间的关联。

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OBJECTIVE: Depression has been related to a higher risk of developing coronary heart disease, but the mechanism that accounts for this association is unclear. Because atherosclerosis is an inflammatory process, depression could increase the risk of coronary heart disease by inducing or promoting inflammation. The objective of the present study was to investigate the association between history of major depressive episode and presence of low-grade systemic inflammation as measured by serum C-reactive protein (CRP). METHODS: We analyzed data from the Third National Health and Nutrition Examination Survey, a representative sample of the US population from 1988 to 1994. Participants included a total of 6149 individuals aged 17 to 39 years who were free of cardiovascular diseases and chronic inflammatory conditions. The main predictor variable of interest was lifetime history of a major depressive episode as assessed by means of the Diagnostic Interview Schedule. The main outcome variable was the presence or absence of an elevated CRP level (> or =22 mg/dl). RESULTS: Among men, history of a major depressive episode was associated with elevated CRP, particularly for recent episodes (up to 6 months before assessment). In multivariate analyses, men with a history of major depressive episode had 2.77 times higher odds of elevated CRP compared with never-depressed men (95% confidence interval, 1.43-5.26). The adjusted odds ratio was 3.81, 3.98, 1.51, and 1.52 for men who had their last major depressive episode less than 1 month before, 1 to 6 months before, 7 to 12 months before, and more than 12 months before assessment, respectively (p for trend =.004). In women, a comparable association between depression and CRP was quite weak and not significant. CONCLUSIONS: A recent history of major depressive episode is strongly associated with elevated CRP in men aged 17 to 39. In this group, low-grade systemic inflammation could represent a mechanism linking depression to cardiovascular risk.
机译：目的：抑郁症与罹患冠心病的风险较高有关，但导致这种关联的机制尚不清楚。由于动脉粥样硬化是一种炎症过程，因此抑郁症可通过诱发或促进炎症而增加患冠心病的风险。本研究的目的是调查严重抑郁发作史与低度全身性炎症的存在之间的关联，该关联可通过血清C反应蛋白（CRP）进行测量。方法：我们分析了第三次全国健康和营养检查调查（1988年至1994年美国人口的代表性样本）的数据。参与者包括6149名年龄在17至39岁之间的无心血管疾病和慢性炎症性疾病的个体。感兴趣的主要预测变量是通过诊断性访谈时间表评估的严重抑郁发作的终生史。主要结果变量是存在或不存在升高的CRP水平（>或= 22 mg / dl）。结果：在男性中，主要的抑郁发作史与CRP升高有关，尤其是对于最近的发作（评估前长达6个月）。在多变量分析中，具有严重抑郁发作史的男性比未抑郁的男性具有更高的CRP机率2.77倍（95％置信区间，1.43-5.26）。对于最后一次严重抑郁发作的男性，在评估前不到1个月，评估前1到6个月，评估前7到12个月，以及评估前12个月以上的男性，调整后的优势比分别为3.81、3.98、1.51和1.52（ p代表趋势= .004）。在女性中，抑郁症和CRP之间的可比性关联相当弱，并不显着。结论：最近的一次重大抑郁发作史与17至39岁男性的CRP升高密切相关。在这一组中，低度全身性炎症可能代表了将抑郁症与心血管风险联系起来的机制。

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