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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Socioeconomic status, stress, and immune markers in adolescents with asthma.
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Socioeconomic status, stress, and immune markers in adolescents with asthma.

机译：哮喘青少年的社会经济状况，压力和免疫指标。

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OBJECTIVE: Previous research has demonstrated links between low socioeconomic status (SES) and clinical asthma outcomes, as well as links between stress and asthma. The objective of this study was to test whether adolescents with asthma from different SES backgrounds differed in biological profiles relevant to asthma, including immune and cortisol measures. The second objective was to test whether psychological stress and control beliefs could explain these differences. MATERIALS AND METHODS: Adolescents with persistent asthma from either low (N= 18) or high (N= 12) SES neighborhoods were interviewed about their stress experiences (chronic stress, acute life events, interpretations of ambiguous life events) and control beliefs. Blood was drawn to assess immune (cytokines, eosinophils, IgE) and neuroendocrine (cortisol) markers associated with asthma. RESULTS: Adolescents in the low SES group had significantly higher levels of a stimulated cytokine associated with a Th-2 immune response (IL-5), higher levels of a stimulated cytokine associated with a Th-1 immune response (IFN-gamma), and marginally lower morning cortisol values compared with the high SES group. Low SES adolescents also had greater stress experiences and lower beliefs about control over their health. Statistical mediational analyses revealed that stress and control beliefs partially explained the relationship between SES and IL-5/IFN-gamma. CONCLUSION: Our finding that low SES was associated with elevations in certain immune responses (IL-5/IFN-gamma) in adolescents with asthma suggests the importance of further exploration into relationships between SES and Th-2/Th-1 responses in asthma. Our findings also suggest that psychological stress and control beliefs may provide one explanation for links between SES and immune responses in childhood asthma.
机译：目的：先前的研究已经证明了低社会经济地位（SES）与临床哮喘预后之间的联系，以及压力与哮喘之间的联系。这项研究的目的是测试来自不同SES背景的青少年哮喘在与哮喘相关的生物学特征（包括免疫和皮质醇测量）方面是否存在差异。第二个目标是测试心理压力和控制信念是否可以解释这些差异。材料和方法：对来自低（N = 18）或高（N = 12）SES社区的患有持续性哮喘的青少年进行了采访，了解他们的压力经历（慢性压力，急性生活事件，模棱两可的生活事件的解释）和控制信念。抽血以评估与哮喘相关的免疫（细胞因子，嗜酸性粒细胞，IgE）和神经内分泌（皮质醇）标志物。结果：低SES组中的青少年与Th-2免疫应答（IL-5）相关的受刺激的细胞因子水平显着较高，与Th-1免疫应答相关的受刺激的细胞因子（IFN-γ）较高水平，与高SES组相比，早晨皮质醇值略低。低SES青少年的压力体验也更大，而对健康控制的信念却较低。统计中介分析显示，压力和控制信念部分解释了SES与IL-5 /IFN-γ之间的关系。结论：我们的发现SES水平低下与哮喘青少年的某些免疫反应（IL-5 /IFN-γ）升高有关，这表明进一步探索哮喘中SES和Th-2 / Th-1反应之间的关系非常重要。我们的发现还表明，心理压力和控制信念可能为儿童哮喘中SES与免疫反应之间的联系提供一种解释。

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