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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Adherence to antipsychotic and nonpsychiatric medications in middle-aged and older patients with psychotic disorders.
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Adherence to antipsychotic and nonpsychiatric medications in middle-aged and older patients with psychotic disorders.

机译：在患有精神病的中老年患者中坚持使用抗精神病药和非精神病药。

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OBJECTIVE: The prevalence and consequences of nonadherence to antipsychotic medications in schizophrenia and related psychotic disorders have been well described; however, little is known about adherence to medications for nonpsychiatric conditions in patients with psychotic disorders. We wished to determine medication adherence in nondemented middle-aged and older Veterans Affairs outpatients with schizophrenia or other psychotic disorders who had been prescribed oral medications for hypertension, hyperlipidemia, or diabetes. METHODS: Medication adherence was assessed by review of medication fill records for 76 patients aged 40 years and older who had been prescribed an oral antipsychotic in addition to an oral agent for hypertension (N = 60), hyperlipidemia (N = 28), or diabetes (N = 24). Up to 12 months of therapy was reviewed, and a compliant fill rate (the number of adherent fills in proportion to the total number of prescription fills) and cumulative mean gap ratio (the number of days when medication was unavailable in relation to the total number of days) were calculated for each medication. RESULTS: The 12-month mean compliant fill rates for antipsychotics, antihypertensives, antihyperlipidemics, and antidiabetics ranged from 52% to 64%. Nonpsychiatric medication adherence rates were similar in patients on typical vs. atypical antipsychotics and did not correlate significantly with antipsychotic adherence rates. CONCLUSIONS: Nonadherence rates were found to be equally problematic for both antipsychotic and nonpsychiatric medications in middle-aged and older patients with psychotic disorders. Interventions to improve adherence to both antipsychotic and nonpsychiatric medications are needed.
机译：目的：对精神分裂症及相关精神疾病中不坚持使用抗精神病药物的患病率和后果进行了详尽的描述。但是，对于患有精神病的患者在非精神疾病中坚持使用药物知之甚少。我们希望确定患有精神分裂症或其他精神病的非痴呆中老年和老年退伍军人事务门诊患者的药物依从性，这些患者已为高血压，高脂血症或糖尿病开了口服药。方法：对76名40岁及40岁以上的患者进行了药物填充记录的评估，评估了药物的依从性，这些患者除口服高血压药（N = 60），高脂血症（N = 28）或糖尿病外，还口服了口服抗精神病药（N = 24）。复查了长达12个月的治疗，并记录了符合率的填充率（依从性填充物的数量与处方填充物的总数成比例）和累积平均差距比（相对于总数，不可用药物的天数）每种药物的使用天数）。结果：抗精神病药，抗高血压药，抗高血脂药和抗糖尿病药的12个月平均依从填充率介于52％至64％之间。在非典型抗精神病药和非典型抗精神病药中，非精神科药物的依从率相似，并且与抗精神病药的依从率没有显着相关性。结论：在中老年精神病患者中，抗精神病药和非精神病药的不依从率同样存在问题。需要采取干预措施来提高对抗精神病药和非精神病药的依从性。

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