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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Cortisol, Hunger, and Desire to Binge Eat Following a Cold Stress Test in Obese Women With Binge Eating Disorder.
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Cortisol, Hunger, and Desire to Binge Eat Following a Cold Stress Test in Obese Women With Binge Eating Disorder.

机译：在患有暴饮暴食症的肥胖女性进行冷应激测试后，皮质醇，饥饿和渴望暴饮暴食。

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OBJECTIVE: Increased basal cortisol levels have been found in bulimia nervosa. After stress, increased cortisol levels have been associated with increased food intake in healthy women. Therefore, we assessed cortisol, hunger, and desire to binge eat after a cold pressor test (CPT) among women with binge eating disorder (BED). METHODS: Twenty-two obese (body mass index [BMI] = 36.7 +/- 6.5 SD) females (11 non-BED, 11 BED) completed the Zung depression scale and underwent the CPT, hand submerged in ice water for 2 minutes. Over 60 minutes, periodic ratings of hunger and desire to binge eat were obtained, just before blood draws for cortisol, as well as insulin. On a separate day, participants had a 1-mg oral dexamethasone suppression test (DST). RESULTS: The BED group had higher depression scores than the non-BED (p = .04), but depression was not a significant covariate for the cortisol response or to DST. After controlling for contraceptive use (n = 3), the BED group had higher basal cortisol than the non-BED group (p = .03), but cortisol did not differ after DST (p = .40). The BED group had nearly significant greater cortisol AUC after the CPT (p = .057) after controlling for insulin AUC and contraceptive use (p = .057). The BED group also had greater AUC for hunger (p = .03) and desire to binge eat (p = .02) after the CPT.CONCLUSION: These findings support our hypothesis of a hyperactive HPA-axis in BED, which may contribute to greater hunger and binge eating.
机译：目的：在神经性贪食症中发现基础皮质醇水平升高。压力过后，健康女性的皮质醇水平升高与食物摄入量增加有关。因此，我们在暴饮暴食症（BED）的妇女中进行了冷加压试验（CPT）后评估了皮质醇，饥饿和暴饮暴食的意愿。方法：22名肥胖（体重指数[BMI] = 36.7 +/- 6.5 SD）女性（11位非BED，11位BED）完成Zung抑郁量表并接受了CPT，将手浸入冰水中2分钟。在60分钟内，就在抽取血液中的皮质醇和胰岛素之前，获得了对饥饿和暴饮暴食的定期评估。在另一天，参与者进行了1毫克口服地塞米松抑制试验（DST）。结果：BED组的抑郁评分高于非BED组（p = .04），但抑郁并不是皮质醇反应或DST的显着协变量。在控制避孕使用（n = 3）后，BED组的基础皮质醇水平高于非BED组（p = .03），但DST后皮质醇无差异（p = .40）。在控制了胰岛素AUC和避孕药的使用之后（P = .057），BED组在CPT后的皮质醇AUC明显升高（p = .057）。 BED组在CPT后还具有更大的饥饿AUC（p = .03）和渴望暴饮暴食（p = .02）的结论。这些结论支持我们关于BED HPA轴过度活跃的假设，这可能有助于饥饿和暴饮暴食。

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