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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Microarousals During Sleep Are Associated With Increased Levels of Lipids, Cortisol, and Blood Pressure.
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Microarousals During Sleep Are Associated With Increased Levels of Lipids, Cortisol, and Blood Pressure.

机译：睡眠中的微耳与脂质，皮质醇和血压水平升高相关。

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OBJECTIVE: Previous work has demonstrated a link between restricted sleep and risk indicators for cardiovascular and metabolic disease, such as levels of cortisol, lipids, and glucose. The present study sought to identify relations between polysomnographic measures of disturbed sleep (frequency of arousals from sleep, total sleep time, and sleep efficiency) and a number of such indicators. A second purpose was to relate the number of arousals to mood, stress, work characteristics, and other possible predictors in daily life. METHODS: Twenty-four people (10 men, 14 women; mean age 30 years), high vs. low on burnout, were recruited from a Swedish IT company. Polysomnographically recorded sleep was measured at home before a workday. Blood pressure, heart rate, morning blood sample, and saliva samples of cortisol were measured the subsequent working day. They were also recorded for diary ratings of sleep and stress, and a questionnaire with ratings of sleep, stress, work conditions, and mood was completed.RESULTS: A stepwise regression analysis using sleep parameters as predictors brought out number of arousals as the best predictor of morning cortisol (serum and saliva), heart rate, systolic and diastolic blood pressure, total cholesterol, high-density lipoprotein (HDL)-, low-density lipoprotein (LDL)-cholesterol, and LDL/HDL-ratio. Work stress/unclear boundaries between work and leisure time was the best predictor of arousals among the stress variables.CONCLUSION: Consistent with sleep restriction experiments, sleep fragmentation was associated with elevated levels of metabolic and cardiovascular risk indicators of stress-related disorders. Number of arousals also seems to be related to workload/stress.
机译：目的：以前的工作表明睡眠受限与心血管疾病和代谢疾病的风险指标（例如皮质醇，脂质和葡萄糖水平）之间存在联系。本研究试图确定多导睡眠图测量的睡眠紊乱（觉醒频率，总睡眠时间和睡眠效率）与许多此类指标之间的关系。第二个目的是将唤醒次数与情绪，压力，工作特征以及日常生活中其他可能的预测因素相关联。方法：从瑞典一家IT公司招募了二十四名（职业倦怠高或低）的人（10名男性，14名女性;平均年龄30岁）。多导睡眠图记录的睡眠是在工作日之前在家中测量的。在随后的工作日测量血压，心率，早晨血液样本和皮质醇的唾液样本。还记录了他们对睡眠和压力的日记评分，并完成了对睡眠，压力，工作条件和情绪评分的问卷调查。结果：使用睡眠参数作为预测因子的逐步回归分析得出了唤醒次数作为最佳预测因子皮质醇（血清和唾液），心率，收缩压和舒张压，总胆固醇，高密度脂蛋白（HDL）-，低密度脂蛋白（LDL）-胆固醇和LDL / HDL比率。结论：与睡眠限制实验一致，睡眠破碎与压力相关疾病的代谢水平和心血管危险指标升高有关。唤醒的次数似乎也与工作量/压力有关。

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