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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Hostility scores are associated with increased risk of cardiovascular events in women undergoing coronary angiography: a report from the NHLBI-Sponsored WISE Study.
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Hostility scores are associated with increased risk of cardiovascular events in women undergoing coronary angiography: a report from the NHLBI-Sponsored WISE Study.

机译：NHLBI赞助的WISE研究报告指出，敌意分数与接受冠状动脉造影的妇女发生心血管事件的风险增加相关。

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OBJECTIVE: To evaluate hostility-related personality traits assessed by the Cook Medley Hostility Inventory and to relate these to the occurrence of adverse cardiac events in women with suspected myocardial ischemia. METHODS: The cohort included 506 women with suspected coronary artery disease from the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study. We examined individual components of the Cook Medley Hostility Score (CMHS) measuring cynicism, hostile affect, and aggressive responding, and a total CMHS (sum of these three) and associations with adverse events (defined as hospitalization for angina, nonfatal myocardial infarction, stroke, congestive heart failure (CHF) other vascular events and death) during 3 to 6 years follow-up using Cox proportional hazard modeling. RESULTS: Women with adverse events had higher total CMHS (10.6 +/- 5.5) than women without any of these events (9.2 +/- 5.1) p = .02. They also had poorer survival by Kaplan-Meier analysis (log-rank p < .05). Unadjusted Cox models showed that the individual scores of cynicism and aggressive responding and the total CMHS were associated with more adverse events (all p < .05). Women with total CMHS above the median had a 35% increase risk of an adverse event in comparison to women with lower scores. In a risk-adjusted Cox model, the hazard ratio for an adverse event was 1.5 (p = .03) for women with total CMHS above the median. CONCLUSION: In this cohort of women with suspected myocardial ischemia, higher Cook Medley scores reflecting cynicism, hostile affect, and aggressive responding were associated with poorer 3 to 6 year event-free survival and a higher risk of adverse events. After adjusting for risk factors and CAD, the association with risk for adverse events increased.
机译：目的：评估由库克·梅德利（Cook Medley）敌意调查表评估的与敌意相关的人格特质，并将其与怀疑患有心肌缺血的妇女发生的不良心脏事件相关联。方法：该队列包括来自美国国家心脏，肺和血液研究所发起的妇女局部缺血综合症评估（WISE）研究的506名怀疑患有冠状动脉疾病的妇女。我们检查了库克·梅德利（Cho Medley）敌对度评分（CMHS）的各个组成部分，以衡量犬儒主义，敌对情绪和攻击性反应以及总CMHS（这三项之和）以及与不良事件（定义为因心绞痛，非致命性心肌梗塞，中风的住院治疗）的相关性，充血性心力衰竭（CHF），其他血管事件和死亡）在3至6年的随访中使用Cox比例风险建模。结果：发生不良事件的女性的总CMHS（10.6 +/- 5.5）比没有发生这些事件的女性（9.2 +/- 5.1）高，p = .02。通过Kaplan-Meier分析，他们的生存率也较差（log-rank p <.05）。未经调整的Cox模型显示，犬儒主义和积极反应的个体评分以及总CMHS与更多不良事件相关（所有p <.05）。与得分较低的女性相比，总CMHS高于中位数的女性发生不良事件的风险增加35％。在风险调整的Cox模型中，总CMHS高于中位数的女性发生不良事件的危险比为1.5（p = .03）。结论：在这组怀疑患有心肌缺血的妇女中，库克·梅德利得分较高（反映犬儒主义，敌对情绪和积极反应）与3至6年无事件生存期较差和发生不良事件的风险较高有关。调整风险因素和CAD后，与不良事件风险的关联性增加。

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