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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Randomized clinical trial of cognitive behavioral stress management on human immunodeficiency virus viral load in gay men treated with highly active antiretroviral therapy.
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Randomized clinical trial of cognitive behavioral stress management on human immunodeficiency virus viral load in gay men treated with highly active antiretroviral therapy.

机译：用高效抗逆转录病毒疗法治疗男同性恋者免疫缺陷病毒病毒载量的认知行为应激管理的随机临床试验。

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OBJECTIVE: Human Immunodeficiency Virus (HIV)-positive individuals treated with highly active antiretroviral therapy (HAART) may experience psychological burdens and negative mood states, which could impair their ability to derive maximum benefits from their medical treatment. We tested whether a cognitive behavioral stress management (CBSM) intervention in combination with antiretroviral medication adherence training (MAT) from a clinical pharmacist influences HIV viral load more than MAT alone. METHODS: HIV-positive men who have sex with men were randomized to either a 10-week CBSM + MAT intervention (n = 76) or a MAT-Only condition (n = 54). Data were collected at baseline immediately following the 10-week intervention period, at 9 months postrandomization, and at 15 months postrandomization. RESULTS: We found no differences in HIV viral load among the 130 men randomized. However, in the 101 men with detectable viral load at baseline, those randomized to CBSM + MAT (n = 61) displayed reductions of 0.56 log10 units in HIV viral load over a 15-month period after controlling for medication adherence. Men in the MAT-Only condition (n = 40) showed no change. Decreases in depressed mood during the intervention period explained the effect of CBSM + MAT on HIV viral load reduction over the 15 months. CONCLUSIONS: A time-limited CBSM + MAT intervention that modulates depressed mood may enhance the effects of HAART on suppression of HIV viral load in HIV+ men with detectable plasma levels.
机译：目的：接受高活性抗逆转录病毒疗法（HAART）治疗的人类免疫缺陷病毒（HIV）阳性患者可能会承受心理负担和负面情绪状态，这可能会削弱他们从医疗中获得最大收益的能力。我们测试了认知行为压力管理（CBSM）干预与临床药剂师的抗逆转录病毒药物依从性训练（MAT）结合是否比单独使用MAT对HIV病毒载量的影响更大。方法：与男性发生性关系的HIV阳性男性被随机分为10周CBSM + MAT干预（n = 76）或仅MAT条件（n = 54）。在10周干预期之后，随机化后9个月和随机化后15个月立即在基线收集数据。结果：我们发现随机分配的130名男性中HIV病毒载量没有差异。但是，在基线时可检测到病毒载量的101名男性中，控制药物依从性后的15个月内，随机分配至CBSM + MAT的男性（n = 61）显示HIV病毒载量减少了0.56 log10个单位。仅接受MAT训练的男性（n = 40）没有变化。干预期间情绪低落的减少解释了CBSM + MAT对15个月内HIV病毒载量减少的影响。结论：限时进行的CBSM + MAT干预可调节情绪低落，可增强HAART对可检测血浆水平的HIV +男性抑制HIV病毒载量的作用。

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