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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Psychosocial and behavioral predictors of inflammation in middle-aged and older adults: the Chicago health, aging, and social relations study.
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Psychosocial and behavioral predictors of inflammation in middle-aged and older adults: the Chicago health, aging, and social relations study.

机译：中老年人炎症的社会心理和行为预测因子：芝加哥健康，衰老和社会关系研究。

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OBJECTIVE: C-reactive protein (CRP) is emerging as an important predictor of cardiovascular disease (CVD), and chronic inflammation may be a mechanism through which stress affects disease risk. We investigated the contribution of behavioral and psychosocial factors to variation in CRP concentrations in a population-based sample of middle-aged and older adults. METHODS: A high sensitivity enzyme-linked immunosorbent assay (ELISA) validated for use with dried blood spot samples was used to determine CRP concentrations in a representative sample of 188 52- to 70-year-olds. Demographic (gender, ethnicity, socioeconomic status), anthropometric (height, weight, waist circumference, percent body fat), behavioral (alcohol consumption, smoking, sleep quality, dietary quality), and psychosocial data (perceived stress, chronic stress, depressive symptoms, loneliness, perceived social support) were collected on the same day as blood samples. Psychosocial variables collected the year before were also used to investigate the impact of changing psychosocial environments. Log-transformed CRP concentrations were examined in a series of nested multivariate regression models. RESULTS: African American and female participants were found to have higher CRP concentrations, as did individuals with lower levels of education. However, ethnic differences disappeared after the addition of behavioral and psychosocial variables. Waist circumference, latency to sleep, smoking, and perceived stress were independently associated with increased concentrations of CRP. CONCLUSIONS: Psychosocial stress, as well as health behaviors, are important predictors of inflammatory activity in a population-based sample and should be considered in future research on inflammation and CVD.
机译：目的：C反应蛋白（CRP）正在成为心血管疾病（CVD）的重要预测指标，慢性炎症可能是压力影响疾病风险的一种机制。我们调查了行为和社会心理因素对以人群为基础的中老年人样本中CRP浓度变化的影响。方法：经验证可用于干血斑样品的高灵敏度酶联免疫吸附测定（ELISA）用于确定188 52至70岁儿童的代表性样品中的CRP浓度。人口统计学（性别，种族，社会经济地位），人体测量学（身高，体重，腰围，体脂百分比），行为（饮酒，吸烟，睡眠质量，饮食质量）和社会心理数据（感知压力，慢性压力，抑郁症状） ，孤独感，可感知的社会支持）与血液样本在同一天收集。前一年收集的社会心理变量还用于调查变化的社会心理环境的影响。在一系列嵌套的多元回归模型中检查了对数转换后的CRP浓度。结果：发现非洲裔美国人和女性参与者的CRP浓度较高，受教育程度较低的人也是如此。但是，在添加了行为和社会心理变量后，种族差异消失了。腰围，睡眠潜伏期，吸烟和感觉到的压力与CRP浓度升高独立相关。结论：社会心理压力以及健康行为是基于人群的样本中炎症活动的重要预测指标，应在以后的炎症和CVD研究中予以考虑。

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