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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Anxiety, depression, and cause-specific mortality: the HUNT study.
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Anxiety, depression, and cause-specific mortality: the HUNT study.

机译：焦虑，抑郁和特定病因死亡率：HUNT研究。

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OBJECTIVE: To investigate empirically the association between anxiety/depression and cause-specific mortality with particular attention to the underlying mechanisms and causes of death. Depression reportedly increases general mortality. For cause-specific mortality, there is evidence depression has an effect on cardiovascular disease (CVD) mortality and suicide. Less information is known as to other mortality diagnoses. There is scarce and conflicting literature on anxiety in relation to mortality. METHODS: Employing a historical cohort design, we used a link between an epidemiological cohort study and a comprehensive national mortality database. We gathered baseline information on physical and mental health (Hospital Anxiety and Depression Scale, HADS) from the population-based health study (n = 61,349). Causes of death were registered with International Classification of Diagnoses, 10th edition (ICD-10) during mean follow-up of 4.4 years. RESULTS: Case-level depression increased the mortality rate for all major disease-related causes of death, whereas case-level anxiety and comorbid anxiety/depression did not. The effect of depression was similar for cardiac mortality compared with all other causes combined, and confounding effects were also very similar. Symptom load of anxiety was associated negatively with both CVD and other cause mortality in fully adjusted models. Accidents and suicide were associated primarily with comorbid anxiety/depression. CONCLUSIONS: Depression is a risk factor for all major disease-related causes of death; it is not limited to CVD mortality or suicide. Because the association between depression and cardiac mortality was comparable to the other causes of death combined and confounding and mediating factors were markedly similar, future investigation as to the mechanisms underlying the effect of depression on mortality should not be limited to CVD mortality.
机译：目的：通过实证研究焦虑/抑郁与特定原因死亡率之间的关系，并特别注意潜在的机制和死亡原因。据报道，抑郁症会增加总体死亡率。对于特定原因的死亡率，有证据表明抑郁症会对心血管疾病（CVD）的死亡率和自杀产生影响。关于其他死亡率诊断的信息较少。关于死亡率的焦虑的文献稀少而矛盾。方法：采用历史队列设计，我们使用了流行病学队列研究与全面的国家死亡率数据库之间的链接。我们从基于人口的健康研究（n = 61,349）中收集了有关身心健康的基线信息（医院焦虑和抑郁量表，HADS）。在4.4年的平均随访中，死亡原因已在《国际诊断分类》（第10版）中进行了记录。结果：病例级抑郁症增加了所有与疾病相关的主要死亡原因的死亡率，而病例级焦虑症和合并症焦虑症/抑郁症却没有。与所有其他原因的总和相比，抑郁对心脏死亡率的影响相似，混杂影响也非常相似。在完全调整的模型中，焦虑的症状负荷与CVD和其他原因死亡率均呈负相关。事故和自杀主要与合并症焦虑/抑郁有关。结论抑郁是所有与疾病相关的主要死亡原因的危险因素。它不仅限于CVD死亡率或自杀。由于抑郁症和心脏死亡率之间的关联性可与其他死亡原因相提并论，并且混杂因素和介导因素明显相似，因此关于抑郁症对死亡率的潜在机制的未来研究不应仅限于CVD死亡率。

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