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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Negative affect and chemical intolerance as risk factors for building-related symptoms: a controlled exposure study.
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Negative affect and chemical intolerance as risk factors for building-related symptoms: a controlled exposure study.

机译：负面影响和化学不耐受是与建筑相关的症状的危险因素：对照暴露研究。

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OBJECTIVE: To assess whether differences in negative affect (NA) and chemical intolerance (CI) affect responses to chemical mixtures and stress in a controlled experimental model. METHODS: Participants were 130 nonsmoking, healthy women, recruited from a university community. Participants completed the Positive and Negative Affect Scale and the Chemical Odor Intolerance Index. In separate sessions 1 week apart, they were exposed to volatile organic compounds (VOCs), VOCs with ozone (VOCs+O3), and ambient or filtered air with a 1-minute spike of VOCs (masked clean air). During each session, half of the participants performed a videotaped speech stressor and half performed simple arithmetic. Before, during, and after each session, salivary cortisol samples were collected, and subjects completed neurobehavioral tests and used a ratio scale to rate physical, cognitive, and anxiety symptoms. RESULTS: Relative to low NA or low CI, neither the high NA nor the high CI groups reported significantly more symptoms in response to any exposure condition. High NA subjects reported more anxiety symptoms in response to the speech stressor but did not have higher cortisol than low NA subjects. High NA subjects, however, were more distressed by the experimental conditions than were low NA subjects. Low NA subjects reported more severe anxiety in the VOCs+O3 with psychological stress condition. CONCLUSIONS: Subjects high in NA were more anxious after a stressor but were not more physically symptomatic in response to increasing chemical exposures. A disposition toward high or low CI did not result in a differential symptomatic response to controlled chemical exposures.
机译：目的：在受控实验模型中，评估负面影响（NA）和化学耐受不良（CI）的差异是否影响对化学混合物和压力的反应。方法：参与者是从大学社区招募的130名非吸烟健康女性。参加者完成了积极和消极影响量表和化学气味耐受性指数。在相隔1周的单独会议中，他们接触了挥发性有机化合物（VOC），含臭氧的VOC（VOCs + O3）和环境或过滤后的空气，其中掺有1分钟的VOC峰值（遮盖的清洁空气）。在每个会话中，一半的参与者执行了录像的语音压力源，另一半的参与者进行了简单的算术运算。在每个疗程之前，之中和之后，都收集唾液皮质醇样品，受试者完成了神经行为测试，并使用比例表对身体，认知和焦虑症状进行评分。结果：相对于低NA或低CI，高NA和高CI组均未发现对任何暴露条件有明显反应的症状。高NA受试者报告了对言语应激反应的更多焦虑症状，但没有比低NA受试者更高的皮质醇。但是，高NA受试者比低NA受试者更受实验条件的困扰。低NA受试者在心理压力下报告VOCs + O3更加严重。结论：NA水平高的受试者在受到压力后更加焦虑，但对化学暴露的增加却没有更多的身体症状。高或低CI的倾向不会导致对受控化学暴露的不同症状反应。

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