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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Associations between psychological traits and endothelial function in postmenopausal women.
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Associations between psychological traits and endothelial function in postmenopausal women.

机译：绝经后妇女的心理特征与内皮功能之间的关联。

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OBJECTIVE: The objective of this study was to determine whether psychosocial risk factors for cardiovascular disease (CVD) are associated with impairments in endothelial function and to determine whether use of hormone replacement therapy (HRT) can moderate observed associations among women without prior CVD. METHODS: Flow-mediated dilation was assessed by brachial ultrasound after reactive hyperemia in 193 postmenopausal women enrolled in the prospective Healthy Women Study. Measures of psychosocial characteristics had been completed at study entry, when the women were premenopausal (mean = 13.6 years earlier), and at a separate postmenopausal follow-up exam near the time of the ultrasound (mean = 1.5 years earlier). RESULTS: Factor analyses of the psychosocial characteristics yielded two factors: Type A/anger and anxiety/depression. Anxiety/depression scores at the study entry and follow-up exams and Type A/anger scores at the study entry exam were associated with less vasodilation (p values < 0.05).Type A/anger scores at the follow-up exam were associated with less vasodilation among women not using HRT (p <.05). CONCLUSIONS: Psychosocial risk factors for CVD are associated with impaired brachial artery dilation among postmenopausal women. HRT use may mask some associations between psychosocial risk factors and endothelial dysfunction among postmenopausal women.
机译：目的：本研究的目的是确定心血管疾病（CVD）的社会心理危险因素是否与内皮功能受损有关，并确定是否使用激素替代疗法（HRT）可以缓解未曾患有CVD的女性之间的相关观察。方法：对193名参加前瞻性“健康女性研究”的绝经后女性进行反应性充血后，通过肱动脉超声评估血流介导的扩张。在研究开始时，即妇女绝经前（平均= 13.6岁），以及在接近超声检查时进行一次单独的绝经后随访检查（平均= 1.5年），已经完成了心理社会特征的测量。结果：心理社会特征的因素分析产生两个因素：A型/愤怒和焦虑/抑郁。入学和随访检查中的焦虑/抑郁评分与入学检查中的A型/愤怒评分与较少的血管舒张相关（p值<0.05）。不使用HRT的女性的血管舒张较少（p <.05）。结论：CVD的社会心理危险因素与绝经后妇女肱动脉扩张受损有关。使用HRT可能掩盖了绝经后妇女心理社会危险因素与内皮功能障碍之间的某些关联。

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