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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Differential mobilization of functionally distinct natural killer subsets during acute psychologic stress.
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Differential mobilization of functionally distinct natural killer subsets during acute psychologic stress.

机译：在急性心理应激过程中功能不同的自然杀手亚群的差异动员。

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OBJECTIVE AND METHODS: Two functionally distinct natural killer (NK) subsets can be identified according to surface CD56 expression: CD56lo cells compose the majority of NK cells and function as cytotoxic cells, whereas CD56hi cells have an immunomodulatory function through the secretion of cytokines. These NK subsets also differ in the expression levels of adhesion molecules such as CD62L and CD11a, indicating distinct potentials to migrate to lymphoid and nonlymphoid tissues. We investigated whether NK cell mobilization during acute stress varies according to these functional and phenotypic distinctions. METHODS AND RESULTS: Fifty-three undergraduate students performed a public-speaking task and 21 students participated in a control session. The task increased heart rate and catecholamines. No change was observed for the immunoregulatory CD56hi NK subset, whereas the number of cytotoxic CD56lo NK cells tripled. In line with the observation that NK mobilization is related to cytotoxic function, we found larger increases in NK cells that express higher levels of CD16 (a receptor that mediates antibody-dependent cytotoxicity). Consistent with known subset differences in adhesion molecule expression, we also found larger stress-induced increases for NK cells that were CD62L-negative and CD11ahi. Plasma levels of soluble CD62L remained unaltered, suggesting that the increase in CD62L-negative NK cells did not result from CD62L shedding. Regression analyses demonstrated independent contributions of epinephrine and norepinephrine to NK subset mobilization. CONCLUSION: The marked specificity and robustness of these effects support the idea that NK cell mobilization is a functionally relevant response that is aimed at protecting the organism during acutely stressful situations.
机译：目的和方法：根据表面CD56的表达可以鉴定出两个功能不同的自然杀伤（NK）亚型：CD56lo细胞构成大部分NK细胞并具有细胞毒性细胞的功能，而CD56hi细胞则通过分泌细胞因子具有免疫调节功能。这些NK亚型在粘附分子（例如CD62L和CD11a）的表达水平上也有所不同，表明迁移到淋巴和非淋巴组织的潜能不同。我们调查了急性应激期间NK细胞的动员是否根据这些功能和表型的差异而变化。方法和结果：53名大学生完成了演讲任务，有21名学生参加了一次控制会议。这项任务增加了心率和儿茶酚胺。免疫调节性CD56hi NK细胞亚群未见变化，而细胞毒性CD56lo NK细胞数量增加了两倍。与NK动员与细胞毒性功能相关的观察一致，我们发现表达更高水平的CD16（介导抗体依赖性细胞毒性的受体）的NK细胞增加较多。与粘附分子表达的已知亚组差异一致，我们还发现CD62L阴性和CD11ahi NK细胞的应激诱导的增加更大。血浆可溶性CD62L的水平保持不变，表明CD62L阴性NK细胞的增加不是由于CD62L脱落所致。回归分析表明肾上腺素和去甲肾上腺素对NK亚组动员的独立贡献。结论：这些作用的显着特异性和稳健性支持以下观点：NK细胞动员是功能相关的反应，旨在在急性应激状态下保护生物体。

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