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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Life stress and cervical squamous intraepithelial lesions in women with human papillomavirus and human immunodeficiency virus.
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Life stress and cervical squamous intraepithelial lesions in women with human papillomavirus and human immunodeficiency virus.

机译：人乳头瘤病毒和人免疫缺陷病毒妇女的生活压力和宫颈鳞状上皮内病变。

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OBJECTIVE: Human immunodeficiency virus (HIV)-infected women are at risk for cervical intraepithelial neoplasia (CIN) and cancer due to impaired immunosurveillance over human papillomavirus (HPV) infection. Life stress has been implicated in immune decrements in HIV-infected individuals and therefore may contribute to CIN progression over time. The purpose of this study was to determine whether life stress was associated with progression and/or persistence of squamous intraepithelial lesions (SIL), the cytologic diagnosis conferred by Papanicolaou smear, after 1-year follow-up among women co-infected with HIV and HPV. METHOD: Thirty-two HIV-infected African-American and Caribbean-American women underwent a psychosocial interview, blood draw, colposcopy, and HPV cervical swab at study entry. Using medical chart review, we then abstracted SIL diagnoses at study entry and after 1-year follow-up. RESULTS: Hierarchical logistic regression analysis revealed that higher life stress increased the odds of developing progressive/persistent SIL over 1 year by approximately seven-fold after covarying relevant biological and behavioral control variables. CONCLUSIONS: These findings suggest that life stress may constitute an independent risk factor for SIL progression and/or persistence in HIV-infected women. Stress management interventions may decrease risk for SIL progression/persistence in women living with HIV.
机译：目的：由于对人类乳头瘤病毒（HPV）感染的免疫监测受损，感染人类免疫缺陷病毒（HIV）的妇女处于宫颈上皮内瘤变（CIN）和癌症的风险中。生活中的压力与艾滋病毒感染者的免疫功能下降有关，因此可能随着时间的推移促进CIN进展。这项研究的目的是确定在合并感染艾滋病毒和艾滋病的妇女进行了1年的随访后，生活压力是否与鳞状上皮内病变（SIL）的进展和/或持续存在有关，这是巴氏涂片检查所赋予的细胞学诊断。 HPV。方法：32名HIV感染的非裔美国人和加勒比裔妇女在研究进入时接受了社会心理访谈，抽血，阴道镜检查和HPV宫颈拭子检查。然后使用病历表审查，在研究进入和1年随访后抽象出SIL诊断。结果：分层逻辑回归分析显示，较高的生活压力在改变相关的生物学和行为控制变量后，在1年内发展进行性/持续性SIL的几率增加了约7倍。结论：这些发现表明生活压力可能构成感染艾滋病毒的妇女SIL进展和/或持续存在的独立危险因素。压力管理干预措施可以降低艾滋病毒携带者的SIL病情恶化/持续性风险。

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