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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Healthy older adults' sleep predicts all-cause mortality at 4 to 19 years of follow-up.
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Healthy older adults' sleep predicts all-cause mortality at 4 to 19 years of follow-up.

机译：健康的老年人睡眠可预测在4到19年的随访中全因死亡率。

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OBJECTIVE: Evidence concerning whether sleep disturbances in older adults predict mortality is mixed. However, data are limited to self-reported sleep problems and may be confounded with other comorbidities. We examined whether electroencephalographic (EEG) sleep parameters predicted survival time independently of known predictors of all-cause mortality. METHODS: A total of 185 healthy older adults, primarily in their 60s through 80s, with no history of mental illness, sleep complaints, or current cognitive impairment, were enrolled in one of eight research protocols between October 1981 and February 1997 that included EEG sleep assessments. At follow-up (mean [SD] = 12.8 [3.7] years after baseline, range = 4.1-19.5), 66 individuals were positively ascertained as deceased and 118 remained alive (total N = 184). RESULTS: Controlling for age, gender, and baseline medical burden, individuals with baseline sleep latencies greater than 30 minutes were at 2.14 times greater risk of death (p =.005, 95% CI = 1.25-3.66). Those with sleep efficiency less than 80% were at 1.93 times greater risk (p =.014, CI = 1.14-3.25). Individuals with rapid eye movement (REM) sleep percentages in the lowest 15% or highest 15% of the total sample's distribution (percentage of REM <16.1 or >25.7) were at 1.71 times greater risk (p =.045, CI = 1.01-2.91). Percentage of slow-wave sleep was associated with time to death at the bivariate level, but not after controlling for potential confounders. CONCLUSIONS: Older adults with specific EEG sleep characteristics have an excess risk of dying beyond that associated with age, gender, or medical burden. The findings suggest that interventions to optimize and protect older adults' sleep initiation, continuity, and quality may be warranted.
机译：目的：有关老年人睡眠障碍是否可以预测死亡率的证据不一。但是，数据仅限于自我报告的睡眠问题，并可能与其他合并症混淆。我们检查了脑电图（EEG）睡眠参数是否独立于已知的全因死亡率预测因素来预测生存时间。方法：从1981年10月至1997年2月，共有185名健康老年人参加了八项研究方案之一，主要是60到80年代，他们没有精神疾病，睡眠障碍或当前的认知障碍病史。评估。随访时（基线后平均[SD] = 12.8 [3.7]年，范围= 4.1-19.5），阳性确诊死亡66例，存活118例（总N = 184）。结果：在控制年龄，性别和基线医疗负担的情况下，基线睡眠潜伏期大于30分钟的个体死亡风险高2.14倍（p = .005，95％CI = 1.25-3.66）。睡眠效率低于80％的人的风险高1.93倍（p = .014，CI = 1.14-3.25）。在总样本分布的最低15％或最高15％（REM <16.1或> 25.7的百分比）中具有快速眼动（REM）睡眠百分比的个体患病风险高1.71倍（p = .045，CI = 1.01- 2.91）。在双变量水平上，慢波睡眠的百分比与死亡时间相关，但在控制潜在的混杂因素之后却没有。结论：具有特定脑电图睡眠特征的老年人死亡的风险超过与年龄，性别或医疗负担相关的死亡风险。研究结果表明，可以采取干预措施来优化和保护老年人的睡眠开始，连续性和质量。

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