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Influence of psychological stress on upper respiratory infection--a meta-analysis of prospective studies.

机译:心理压力对上呼吸道感染的影响-前瞻性研究的荟萃分析。

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OBJECTIVE: To quantify the available evidence for the hypothesis that reduced resistance caused by psychological stress may influence the development of clinical disease in those exposed to an infectious agent. METHODS: We conducted a systematic review and meta-analysis of 27 prospective studies examining the association between psychological stress and subsequent upper respiratory infection (URI). RESULTS: The results revealed a significant overall main effect of psychological stress on the risk of developing URI (effect size correlation coefficient, 0.21; 95% confidence interval, 0.15-0.27). Further analyses showed that effect sizes for the association did not vary according to type of stress, how URI was assessed, or whether the studies had controlled for preexposure. CONCLUSIONS: The meta-analytical findings confirmed the hypothesis that psychological stress is associated with increased susceptibility to URI, lending support to an emerging appreciation of the potential importance of psychological factors in infectious disease.
机译:目的:为了量化以下假设的可用证据:心理压力导致的抵抗力降低可能影响暴露于传染原的患者的临床疾病发展。方法:我们对27项前瞻性研究进行了系统的回顾和荟萃分析,研究了心理压力与随后的上呼吸道感染(URI)之间的关系。结果:结果显示心理压力对发生URI的风险具有显着的总体总体影响(效果大小相关系数为0.21; 95%置信区间为0.15-0.27)。进一步的分析表明,该关联的效应大小不会根据压力的类型,URI的评估方式或研究是否控制预暴露而变化。结论:荟萃分析发现证实了心理压力与URI易感性增加相关的假说,为人们逐渐认识到心理因素在传染病中的潜在重要性提供了支持。

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