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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Physiologic dysfunction scores and cognitive function test performance in U.S. adults.
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Physiologic dysfunction scores and cognitive function test performance in U.S. adults.

机译：美国成年人的生理机能障碍评分和认知功能测试表现。

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OBJECTIVE: To investigate the relationship between a measure of cumulative physiologic dysfunction and specific domains of cognitive function. METHODS: We examined a summary score measuring physiologic dysfunction, a multisystem measure of the body's ability to effectively adapt to physical and psychological demands, in relation to cognitive function deficits in a population of 4511 adults aged 20 to 59 who participated in the Third National Health and Nutrition Examination Survey (1988-1994). Measures of cognitive function comprised three domains: working memory, visuomotor speed, and perceptual-motor speed. "Physiologic dysfunction" scores summarizing measures of cardiovascular, immunologic, kidney, and liver functions were explored. We used multiple linear regression models to estimate associations between cognitive function measures and physiologic dysfunction scores, adjusting for socioeconomic factors, test conditions, and self-reported health factors. RESULTS: We noted a dose-response relationship between physiologic dysfunction and working memory (coefficient = 0.207, 95% confidence interval = 0.066-0.348, p < .0001), which persisted after adjustment for all covariates (p = .03). We did not observe any significant relationships between dysfunction scores and visuomotor (p = .37) or perceptual-motor ability (p = .33). CONCLUSIONS: Our findings suggest that multisystem physiologic dysfunction is associated with working memory. Future longitudinal studies are needed to clarify the underlying mechanisms and explore the persistency of this association into later life. We suggest that such studies should incorporate physiologic data, neuroendocrine parameters, and a wide range of specific cognitive domains.
机译：目的：探讨累积生理功能障碍的量度与认知功能的特定领域之间的关系。方法：我们对参加生理学功能障碍的一项综合评分进行了测量，这是对身体有效适应生理和心理需求的能力进行的多系统测量，与参加第三次全国卫生调查的4511位20至59岁成年人的认知功能缺陷有关和营养检查调查（1988-1994年）。认知功能的测量包括三个领域：工作记忆，视觉运动速度和知觉运动速度。探索了“生理功能障碍”评分，总结了心血管，免疫，肾脏和肝脏功能的测量指标。我们使用了多个线性回归模型来估计认知功能量度与生理功能障碍评分之间的关​​联，并根据社会经济因素，测试条件和自我报告的健康因素进行调整。结果：我们注意到生理功能障碍和工作记忆之间存在剂量-反应关系（系数= 0.207，95％置信区间= 0.066-0.348，p <.0001），在对所有协变量进行校正后（p = .03），该关系仍然存在。我们没有观察到功能障碍评分与视觉运动能力（p = .37）或知觉运动能力（p = .33）之间的任何显着关系。结论：我们的发现提示多系统生理功能障碍与工作记忆有关。需要进一步的纵向研究来阐明潜在的机制，并探索这种关联在以后的生活中的持久性。我们建议此类研究应纳入生理数据，神经内分泌参数和广泛的特定认知领域。

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