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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >The association between depression and leptin is mediated by adiposity
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The association between depression and leptin is mediated by adiposity

机译：抑郁与瘦素之间的联系是由肥胖介导的

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Objective: Animal models suggest that impaired leptin production, or leptin resistance despite increased leptin levels, may contribute to depression. The link between leptin and depression could be mediated by obesity, which is more common in depression and increases leptin production. Methods: We administered the Beck Depression Inventory-II (BDI-II) to 537 participants (mean [standard deviation (SD)] age = 51 [9] years; female, 61%) enrolled in the Morehouse and Emory Team up to Eliminate Health Disparities (META-Health) study. Leptin levels were examined as continuous log-transformed values. Results: Participants with moderate to severe depression had higher levels of leptin (median [interquartile range] 37.7 [17.6-64.9] ng/mL) than those with mild depression (22.9 [7.0-57.9] ng/mL) or minimal to no depression (19.8 ng/mL [7.8-39.1], p = .003). Participants with moderate to severe depression had higher body mass index (BMI) than those with mild or minimal depression (mean [SD] = 33 [8] versus 31 [9] versus 29 [7] kg/m 2, p = .001). After multivariate adjustment for age, sex, race, smoking status, hypertension, diabetes, blood pressure, lipids, and C-reactive protein, the BDI-II score remained a significant predictor of leptin levels (β = 0.093, p = .01). Further adjustment for BMI eliminated the association between the BDI-II score and leptin (β = 0.03, p = .3). Adjusting for waist circumference in place of BMI revealed similar findings. Conclusions: The association between depression and leptin seems to be mediated by increased adiposity in depressed individuals. Abbreviations: BDI-II = Beck Depression Inventory-IIBMI = body mass indexHDL-C = high-density lipoprotein cholesterol
机译：目的：动物模型表明，尽管瘦素水平增加，但瘦素生产受损或瘦素抵抗力可能会导致抑郁。肥胖可以介导瘦素与抑郁之间的联系，肥胖在抑郁症中更为常见，并会增加瘦素的产生。方法：我们对参加Morehouse and Emory团队的537名参与者（平均[标准差（SD）]年龄= 51 [9]岁;女性，61％）进行了贝克抑郁量表II（BDI-II）的调查，直至消除健康差异（META-Health）研究。瘦素水平作为连续的对数转换值进行检查。结果：中度至重度抑郁的参与者的瘦素水平（中位[四分位间距] 37.7 [17.6-64.9] ng / mL）高于轻度抑郁（22.9 [7.0-57.9] ng / mL）或最低至无抑郁者（19.8 ng / mL [7.8-39.1]，p = .003）。中度至重度抑郁的参与者的体重指数（BMI）比轻度或轻度抑郁的参与者更高（平均[SD] = 33 [8]相对于31 [9]相对于29 [7] kg / m 2，p = .001 ）。在对年龄，性别，种族，吸烟状况，高血压，糖尿病，血压，脂质和C反应蛋白进行多变量调整后，BDI-II评分仍然是瘦素水平的重要预测指标（β= 0.093，p = .01） 。 BMI的进一步调整消除了BDI-II评分与瘦素之间的关联（β= 0.03，p = .3）。调整腰围代替BMI显示出相似的发现。结论：抑郁症与瘦素之间的联系似乎是由抑郁症个体的肥胖增加所介导的。缩写：BDI-II =贝克抑郁量表-IIBMI =体重指数HDL-C =高密度脂蛋白胆固醇

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