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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Examining the relationship between depression and asthma exacerbations in a prospective follow-up study
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Examining the relationship between depression and asthma exacerbations in a prospective follow-up study

机译：在一项前瞻性随访研究中检查抑郁与哮喘加重之间的关系

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BACKGROUND: Although depression has been linked with asthma, its relationship with asthma exacerbations, including emergency department (ED) visits and oral steroid (OS) use, has not been well documented. The aim is to investigate whether depression increases exacerbations among patients with asthma. METHOD: The study included 568 participants with asthma who were between 18 and 56 years old, were taking an inhaled corticosteroid, and participated in baseline and follow-up surveys. Surveys and medical records from a large, health system were collected as part of the Adherence Feedback for Improving Respiratory Medication Use trial. Number of ED visits and OS prescription fills for asthma were calculated for 12-month periods before and after the follow-up survey. Depression was measured using a standardized two-item instrument. Negative binomial regression and modified proportional hazards models were used. RESULTS: Among patients with asthma, those who had depression (n = 187; 32.9%) were at increased risk for an asthma-related ED visit (adjusted relative risk = 1.96, 95% confidence interval [CI] = 1.02-3.75), but not an OS fill (adjusted relative risk = 0.98; 95% CI = 0.72-1.32). Participants with depression and asthma who received psychiatric treatment via antidepressant medication (n = 126; 22.2%) or psychotherapy (n = 39; 6.9%) were more likely to have an ED visit (medication hazard ratio = 2.09, 95% CI = 1.35-3.25; psychotherapy hazard ratio = 2.07, 95% CI = 1.38-3.22). CONCLUSIONS: This study suggests a temporal relationship between depression and asthma-related ED visits. Research and practice must consider the importance of these comorbid conditions.
机译：背景：尽管抑郁症与哮喘有关，但尚未充分证明其与哮喘加重的关系，包括急诊就诊（ED）和口服类固醇（OS）的使用。目的是研究抑郁症是否会增加哮喘患者的病情加重。方法：该研究纳入了568名18至56岁的哮喘参与者，他们正在吸入糖皮质激素，并参加了基线和随访调查。作为改善呼吸道用药使用的依从性反馈试验的一部分，收集了来自大型卫生系统的调查和医疗记录。在随访调查之前和之后的12个月内，计算了ED访视次数和OS哮喘处方剂量。抑郁症是使用标准化的两件式器械测量的。使用负二项式回归和修正比例风险模型。结果：在哮喘患者中，患有抑郁症的患者（n = 187; 32.9％）与哮喘相关的ED就诊的风险较高（调整后的相对风险= 1.96，95％的置信区间[CI] = 1.02-3.75），但没有OS填充（调整后的相对风险= 0.98; 95％CI = 0.72-1.32）。接受抗抑郁药物（n = 126; 22.2％）或心理治疗（n = 39; 6.9％）的精神病学治疗的患有抑郁症和哮喘的参与者更有可能进行急诊就诊（药物风险比= 2.09，95％CI = 1.35） -3.25;心理治疗危险比= 2.07，95％CI = 1.38-3.22）。结论：这项研究表明抑郁与哮喘相关的ED访视之间存在时间关系。研究和实践必须考虑这些合并症的重要性。

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