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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Thresholds and perception of cold pain, heat pain, and the thermal grill illusion in patients with major depressive disorder
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Thresholds and perception of cold pain, heat pain, and the thermal grill illusion in patients with major depressive disorder

机译：严重抑郁症患者的冷痛，热痛和热格栅幻觉的阈值和感知

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OBJECTIVE: The thermal grill illusion (TGI) in which interlacing cold and warm bars create the illusion of a painful sensation has been suggested as an experimental model for central pain states and pain processing. The aim of this study was to use this technique to gain further insights into the altered pain perception in major depressive disorder (MDD). METHODS: In 18 unmedicated patients with MDD, cold and heat pain thresholds (CPT/HPT) as well as the perception of the TGI were examined and compared with 18 matched controls. RESULTS: CPT and HPT were significantly increased in patients (7.9 C and 47.5 C) compared with controls (15.9 C and 45.2 C, respectively; p < .05). In the range of TGI stimuli that were perceived painful by controls, the patients did not indicate painful sensations, thereby indicating a shift of the stimulus-response curve of TGI pain perception toward higher stimulus intensities, that is, greater temperature differentials between cold and warm bars (11.5 C for controls, 16.7 C for patients). The patients rated the pain intensity perceived at the respective pain thresholds (CPT and HPT) in tendency higher than did the controls, whereas they perceived the TGI less painful despite increased stimulus intensities. Unpleasantness ratings were similar between groups. CONCLUSIONS: CPT, HPT and temperature differentials for the perception of the TGI, were increased in patients with MDD as compared with controls. Pain intensity, however, was rated differently for CPT and HPT, where patients indicated higher ratings in tendency, and for the TGI stimulation, where pain was perceived less intense.
机译：目的：热格栅幻觉（TGI）可以通过交错的冷，暖条产生疼痛感的幻觉，作为中枢性疼痛状态和疼痛处理的实验模型。这项研究的目的是使用这种技术来进一步了解重度抑郁症（MDD）中疼痛感的改变。方法：在18名患有MDD的未经药物治疗的患者中，检查了冷，热痛阈值（CPT / HPT）以及对TGI的感觉，并将其与18名相匹配的对照组进行了比较。结果：与对照组（分别为15.9 C和45.2 C）相比，患者的CPT和HPT显着升高（分别为7.9 C和47.5 C; p <.05）。在对照组感觉到的TGI刺激范围内，患者并未表现出疼痛的感觉，因此表明TGI疼痛感知的刺激反应曲线向较高的刺激强度转移，即冷热之间的温差更大条（对照为11.5 C，患者为16.7 C）。患者对在各自的疼痛阈值（CPT和HPT）处感觉到的疼痛强度的评分高于对照组，而尽管刺激强度增加，他们仍认为TGI的疼痛程度较小。两组之间的不愉快程度相似。结论：与对照组相比，MDD患者的CGI，HPT和TGI感知温差增加。然而，对于CPT和HPT，患者显示出较高的趋势评分，对TGI刺激，对疼痛的感觉不那么强烈，对疼痛强度的评分不同。

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