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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Genetic influence on blood pressure and underlying hemodynamics measured at rest and during stress
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Genetic influence on blood pressure and underlying hemodynamics measured at rest and during stress

机译：遗传对静止和压力下血压和潜在血液动力学的影响

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OBJECTIVE: This study examined the genetic and environmental contributions to the individual differences in blood pressure (BP) levels and underlying hemodynamic characteristics at rest and during mental challenge tasks in a large twin cohort of youth. Including both European American and African American twins further allowed examination of potential ethnic differences. METHODS: We studied cardiovascular reactivity to two stressors (car-driving simulation and a social stressor interview) in 308 European American and 223 African American twin pairs including monozygotic twin pairs and same-sex as well as opposite-sex dizygotic twin pairs (mean [standard deviation] age = 14.7 [3.1]). Variables included systolic and diastolic BP, heart rate, stroke volume, cardiac output, and total peripheral resistance. RESULTS: Heritability indices for levels at rest and during stress were high (31%-73%) and comparable between ethnic groups. A common genetic factor accounted for both resting and stress levels explaining 23% to 58% of the total variance. The increases in heritability indices for BP and heart rate from rest to stress are mostly explained by newly emerging genetic influences on the added stress component. Indices for hemodynamic variables remained stable from rest to stress owing to a simultaneous decrease in genetic and environmental variances. CONCLUSIONS: Cardiovascular measures obtained during rest and stress show substantial heritability that is comparable between individuals of African and European descent. Most of the variance in both resting and stress levels is explained by common genetic factors, although other genetic factors that only contribute to cardiovascular levels during stress are also important.
机译：目的：本研究调查了在一个大的双胞胎青年群体中，在休息和精神挑战任务期间血压（BP）水平和潜在血液动力学特征的个体差异的遗传和环境贡献。包括欧洲裔美国人和非裔美国人双胞胎在内，还可以检查潜在的种族差异。方法：我们研究了308个欧洲和223个非裔美国人双胞胎对中两个应激源（驾驶模拟和社交应激源访谈）的心血管反应，其中包括单卵双生双卵，同性双卵和异性双卵双生卵对（均值[标准偏差] age = 14.7 [3.1]）。变量包括收缩压和舒张压，心率，中风量，心输出量和总外周阻力。结果：休息和压力水平下的遗传指数很高（31％-73％），种族之间具有可比性。一个共同的遗传因素既影响了静息水平又反映了压力水平，解释了总变异的23％至58％。从休息到压力，血压的遗传指数和心率的增加主要是由新出现的遗传因素对增加的压力成分的影响所解释。由于遗传和环境差异的同时减少，血液动力学变量的指标从静止到紧张都保持稳定。结论：在休息和压力期间获得的心血管指标显示出可遗传的遗传力，在非洲人和欧洲人后裔之间是可比的。静息和压力水平的大多数差异是由常见的遗传因素解释的，尽管在压力下仅有助于心血管水平的其他遗传因素也很重要。

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