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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Monoamine oxidase a genotype, childhood trauma, and subclinical atherosclerosis: A twin study
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Monoamine oxidase a genotype, childhood trauma, and subclinical atherosclerosis: A twin study

机译：单胺氧化酶的基因型，儿童期创伤和亚临床动脉粥样硬化：一项孪生研究

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OBJECTIVE: A functional promoter polymorphism in the monoamine oxidase A (MAOA) gene has been implicated in neuropsychiatric disorders and also moderates the association between early-life stress and mental disorders, which often co-occur with cardiovascular disease. No study has examined the relationship between MAOA genotype, childhood trauma, and subclinical atherosclerosis. The objective of this investigation was to examine whether childhood trauma moderates the association between MAOA genotype and subclinical atherosclerosis. METHODS: A sample including 289 middle-aged male twin pairs was studied. Subclinical atherosclerosis was assessed by brachial flow-mediated dilation (FMD) using ultrasound. Childhood trauma, before age 18 years, was measured with the Early Trauma Inventory and included physical, emotional, and sexual abuse as well as general trauma. Generalized estimating equation models were used to test the main and interactive effects of the MAOA genotype and each domain of childhood trauma on FMD, adjusting for known risk factors. RESULTS: General trauma was the most prevalent childhood trauma (28.4%), followed by physical abuse (25.0%), emotional abuse (19.4%), and sexual abuse (11.6%). MAOA genotype was not associated with any domain of childhood trauma. There was no significant evidence for a main effect for the MAOA genotype (β = .02, p = .82) or childhood trauma (.005 < β < .10, p > .54) FMD. However, a significant interaction was observed between MAOA genotype and physical (βinteraction = .37, p = .026) or emotional abuse (βinteraction = .43, p = .025) on subclinical atherosclerosis. CONCLUSIONS: Childhood trauma modulates the impact of MAOA variant on subclinical atherosclerosis, independent of traditional cardiovascular risk factors.
机译：目的：单胺氧化酶A（MAOA）基因的功能性启动子多态性与神经精神疾病有关，并缓解了早期应激与精神疾病之间的关联，而精神疾病通常与心血管疾病同时发生。尚无研究检查MAOA基因型，儿童期创伤与亚临床动脉粥样硬化之间的关系。这项研究的目的是检查儿童期创伤是否减轻了MAOA基因型与亚临床动脉粥样硬化之间的联系。方法：对包括289对中年男性双胞胎的样本进行了研究。亚临床动脉粥样硬化通过使用超声通过肱动脉血流介导的扩张（FMD）进行评估。 18岁以前的儿童创伤是根据《早期创伤》调查的，包括身体，情感和性虐待以及一般创伤。使用广义估计方程模型测试了MAOA基因型和儿童期创伤的各个领域对口蹄疫的主要作用和相互作用，并调整了已知的危险因素。结果：一般创伤是儿童期最普遍的创伤（28.4％），其次是身体虐待（25.0％），情感虐待（19.4％）和性虐待（11.6％）。 MAOA基因型与儿童期创伤的任何领域均无关。没有明显的证据表明MAOA基因型（β= .02，p = .82）或儿童期创伤（.005 <β<.10，p> .54）的主要作用。但是，在亚临床动脉粥样硬化中，观察到了MAOA基因型与身体（β相互作用= .37，p = .026）或情绪虐待（β相互作用= .43，p = .025）之间的显着相互作用。结论：童年创伤调节了MAOA变异对亚临床动脉粥样硬化的影响，独立于传统的心血管危险因素。

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