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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >The effect of intranasal oxytocin administration on acute cold pressor pain: A placebo-controlled, double-blind, within-participants crossover investigation
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The effect of intranasal oxytocin administration on acute cold pressor pain: A placebo-controlled, double-blind, within-participants crossover investigation

机译：鼻内催产素对急性冷压痛的影响：安慰剂对照，双盲，参与者内交叉研究

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BACKGROUND: This study examined the effect of synthetic oxytocin delivered intranasally on acute pain sensitivity using a placebo-controlled, double-blind, within-participant crossover design. METHODS: Thirty-seven (18 were male) pain-free young adults underwent two laboratory sessions separated by 1 week. Each session consisted of baseline, administration, second baseline, pain, and recovery phases, completed in a fixed order. Participants were given an intransal administration of 40 IU oxytocin or placebo. Blood pressure and heart rate (HR) were measured at 1-minute intervals throughout each phase. Pain was induced by submersing the nondominant hand in cold (2°C) water. Pain threshold, intensity, unpleasantness, and Short-Form McGill Pain Questionnaire-2 pain descriptors were rated immediately after pain testing. Mood was assessed using visual analog scales after baseline, second baseline, and pain phases. The second laboratory session was identical to the first, with the exception that a different nasal spray was administered. RESULTS: Participants reported lower pain intensity (50.57 [20.94] versus 56.73 [20.12], p = .047), pain unpleasantness (47.00 [27.24] versus 55.78 [22.46], p = .033), and Short-Form McGill Pain Questionnaire-2 pain descriptors (53.38 [31.18] versus 60.92 [31.17], p = .031) and higher pain threshold (45.70 [59.55] versus 38.35 [59.12], p = .040) after oxytocin administration relative to placebo. There was a nasal spray by phase interaction on HR (p = .006). Pain-related increase in HR was attenuated by oxytocin nasal spray. Systolic and diastolic blood pressure increased during pain testing but were unaffected by nasal spray. CONCLUSIONS: These results suggest that oxytocin can lead to decreased acute pain sensitivity.
机译：背景：这项研究使用安慰剂对照，双盲，参与者内交叉设计检查了鼻内递送的合成催产素对急性疼痛敏感性的影响。方法：37名（18名男性）无痛年轻成人接受了两次为期1周的实验室会议。每个阶段均由基线，给药，第二基线，疼痛和恢复阶段组成，并以固定顺序完成。参与者经皮给予40 IU催产素或安慰剂。在每个阶段中，每隔1分钟测量一次血压和心率（HR）。通过将惯用手浸入冷（2°C）水中来诱发疼痛。疼痛测试后立即评估疼痛阈值，强度，不愉快和简短的McGill疼痛问卷2疼痛描述符。在基线，第二基线和疼痛阶段之后，使用视觉模拟量表评估情绪。第二个实验室会议与第一个实验室会议相同，区别在于使用了不同的鼻喷雾剂。结果：参与者报告的疼痛强度较低（50.57 [20.94]对56.73 [20.12]，p = .047），疼痛不适（47.00 [27.24]对55.78 [22.46]，p = .033）和《 McGill疼痛简短调查表》相对于安慰剂，催产素给药后的-2疼痛描述符（53.38 [31.18]与60.92 [31.17]，p = .031）和较高的疼痛阈值（45.70 [59.55]与38.35 [59.12]，p = .040）。在HR上通过相相互作用进行鼻喷剂（p = .006）。催产素鼻喷雾剂可减轻与疼痛有关的HR升高。疼痛测试期间收缩压和舒张压升高，但不受喷鼻剂的影响。结论：这些结果表明催产素可导致急性疼痛敏感性降低。

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