This present article provides an overview of the results obtained during Denis Morsa's master dissertation. This work has been performed in the laboratory of Mass Spectrometry at University of Liege under the direction of Valerie Gabelica and Edwin De Pauw. Mass spectrometry is an analytical tool dedicated to the separation and the identification of ions according to their mass-to-charge (m/z) ratio. This measurement provides information about the elemental composition and, if a fragmentation pattern is present, about the atomic connectivity of the analyte. However, this information is usually not sufficient to characterize tridimensional structures. Ion mobility spectrometry (IMS) is an adequate tool to assign this problem as it allows to separate ions according to their shape in the gas phase. The coupling between MS and IMS provides a multi-dimensional separation method that has found numerous applications in both separation and structural characterization of molecules, from small entities to polymers and supramolecular complexes.
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机译：本文概述了丹尼斯·莫尔萨（Denis Morsa）硕士论文期间获得的结果。这项工作是在列日大学质谱实验室在Valerie Gabelica和Edwin De Pauw的指导下进行的。质谱分析是一种致力于根据离子的质荷比（m / z）进行分离和鉴定的分析工具。该测量提供了有关元素组成的信息，如果存在碎裂模式，还提供了有关分析物的原子连通性的信息。但是，此信息通常不足以表征三维结构。离子迁移谱（IMS）是解决此问题的合适工具，因为它可以根据离子在气相中的形状分离离子。 MS和IMS之间的耦合提供了一种多维分离方法，该方法在从小实体到聚合物和超分子复合物的分子分离和结构表征中都发现了许多应用。
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