Designing Photoreactive Ruthenium~(II) Complexes for Biomedical Applications

Kevin GARNIR; Lionel MARCELIS; Arsdree KIRSCH-DE MESMAEKER

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Designing Photoreactive Ruthenium~(II) Complexes for Biomedical Applications

机译：设计用于生物医学应用的光反应性钌〜（II）配合物

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The development of therapeutic agents represents one of the main research objectives in the fight against cancer. In this context, the "laboratoire de Chimie Organique et Photochimie" focuses its interest in the design of photoreactive Ruthenium~(II) complexes. The interesting photoreactivity is mainly due to thephotooxidizing properties of complexes bearing π-deficient ligands. It has been demonstrated that a photo-induced electron transfer (PET) is indeed possible between a DNA guanine moiety and a Ru" complex containing at least two π-acceptingligands. Thisprimary PET process can lead to the formation of a photoadduct, in which a covalent link is formed between the Ru~(II) complex and a DNA strand. This covalent bitiding allows the development of gene silencing strategies where two complementary oligonucleotides (ODNs) are irreversibly photocrosslinked.

机译：治疗剂的开发代表了抗癌的主要研究目标之一。在这种情况下，“化学实验室和光化学实验室”将其兴趣集中在光反应性钌（II）配合物的设计上。有趣的光反应性主要是由于带有π缺陷配体的配合物的光氧化性能。已经证明，在DNA鸟嘌呤部分和含有至少两个π-接受配体的Ru”络合物之间确实可能进行光致电子转移（PET）。该主要的PET过程可以导致光加合物的形成，其中Ru〜（II）配合物与DNA链之间形成共价键，这种共价键合可以发展基因沉默策略，其中两个互补寡核苷酸（ODN）不可逆地进行光交联。

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《Chimie Nouvelle》 |2012年第109期|共4页
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Kevin GARNIR; Lionel MARCELIS; Arsdree KIRSCH-DE MESMAEKER;
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1. Designing Photoreactive Ruthenium~(II) Complexes for Biomedical Applications [J] . Kevin GARNIR, Lionel MARCELIS, Arsdree KIRSCH-DE MESMAEKER Chimie Nouvelle . 2012,第109期

机译：设计用于生物医学应用的光反应性钌〜（II）配合物
2. Preparation, stability, and photoreactivity of thiolato ruthenium polypyridyl complexes: Can cysteine derivatives protect ruthenium-based anticancer complexes? [J] . van Rixel Vincent H. S., Busemann Anja, Gottle Adrien J., Journal of Inorganic Biochemistry: An Interdisciplinary Journal . 2015,第Null期

机译：硫醇基钌多吡啶基复合物的制备，稳定性和光反应性：半胱氨酸衍生物可以保护基于钌的抗癌复合物吗？
3. Oligonucleotide Duplexes with Tethered Photoreactive Ruthenium(II) Complexes: Influence of the Ligands and Their Linker on the Photoinduced Electron Transfer and Crosslinking Processes of the Two Strands [J] . Deroo S, Le Gac S, Ghosh S, European journal of inorganic chemistry . 2009,第4期

机译：拴式光反应性钌（II）配合物的寡核苷酸双链体：配体及其连接体对两条链的光诱导电子转移和交联过程的影响
4. Design and synthesis of ruthenium (II) complexes and their applications in dye sensitized solar cells (DSSCs) [C] . Preeyapat Prompan, Kittiya Wongkhan, Rukkiat Jitchati International Conference on Applied Physics and Material Applications . 2013

机译：钌（II）复合物的设计和合成及其在染料敏化太阳能电池（DSSC）中的应用
5. Photochemistry of group 8 metal complexes of type [M(bpy)2 cyanogen] (M = iron, ruthenium). Photosynthesis of heteroleptic iron(II) compounds and photoionization of ruthenium(II) compounds, or, Photoassisted synthesis of heteroleptic iron(II) compounds and photoionization of ruthenium(II) complexes. [D] . Turner, David Benjamin. 2009

机译：[M（bpy）2氰基]类型的第8组金属配合物的光化学（M =铁，钌）。杂合铁（II）化合物的光合作用和钌（II）化合物的光电离，或者杂合铁（II）化合物的光辅助合成和钌（II）配合物的光电离。
6. Dual Photoreactivity of a New Rh2(IIII) Complex for Biological Applications [O] . Regina N. Akhimie, Jessica K. White, Claudia Turro -1

机译：新型Rh2（IIII）配合物在生物应用中的双重光反应性
7. Azobenzene-appended iridium(III) and ruthenium(II) complexes. Screening of applications [O] . Tellería Echaniz Ainara 2016

机译：偶氮苯加铱（III）和钌（II）配合物。筛选申请

Designing Photoreactive Ruthenium~(II) Complexes for Biomedical Applications

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