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首页> 外文期刊>Psychosomatics >The neuropsychiatric complications of glucocorticoid use: steroid psychosis revisited.
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The neuropsychiatric complications of glucocorticoid use: steroid psychosis revisited.

机译：糖皮质激素使用的神经精神疾病并发症：类固醇性精神病再次出现。

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Glucocorticoids are widely prescribed for a variety of diseases and are known to cause neuropsychiatric as well as somatic side effects.This article will review the incidence, clinical characteristics, course, and treatment of neuropsychiatric effects of glucocorticoids.We performed a literature review of the neuropsychiatric complications of glucocorticoids using the PubMed database.The neuropsychiatric effects of glucocorticoids involve affective, behavioral, and cognitive manifestations. Serious neuropsychiatric effects occur in about 6% of patients who receive steroids. Although the effects of glucocorticoids are unpredictable, the administered dose is the most significant risk factor for the development of neuropsychiatric symptoms. Dosage reduction typically results in clinical recovery. Although evidence from controlled trials is sparse, administration of antipsychotics or mood stabilizers may be beneficial in the prevention and treatment of neuropsychiatric effects of steroids.The neuropsychiatric effects of glucocorticoids are more diverse than the often-misleading term "steroid psychosis" suggests. This label should be limited to those patients who are truly psychotic, and specific designations applied to patients with other effects. The adverse neuropsychiatric effects of glucocorticoids remain poorly characterized in the literature (which consists largely of case reports and case series). Reliable risk factors (other than dose) that identify individuals at risk are lacking; guidelines for the prevention of neuropsychiatric effects are not evidence-based. Further controlled clinical studies are needed to elucidate the optimal management of glucocorticoid-induced neuropsychiatric symptoms.
机译：糖皮质激素被广泛用于各种疾病，并已知会引起神经精神病和躯体副作用。本文将回顾糖皮质激素的发生率，临床特征，病程和治疗，我们对神经精神病学进行了文献综述。使用PubMed数据库进行糖皮质激素的并发症治疗。糖皮质激素的神经精神影响涉及情感，行为和认知表现。接受类固醇治疗的患者中约有6％发生严重的神经精神疾病。尽管糖皮质激素的作用是不可预测的，但是给药剂量是神经精神症状发展的最重要的危险因素。减少剂量通常会导致临床恢复。尽管来自对照试验的证据稀少，但服用抗精神病药或情绪稳定剂可能有助于预防和治疗类固醇的神经精神疾病。糖皮质激素的神经精神病作用比经常引起误解的术语“类固醇精神病”所暗示的要多样化。此标签应仅限于真正患有精神病的患者，并且对具有其他作用的患者应使用特定的名称。糖皮质激素的不良神经精神病学作用在文献中仍然很差（主要由病例报告和病例系列组成）。缺乏确定危险个体的可靠危险因素（剂量除外）;预防神经精神病学影响的指导方针不是基于证据的。需要进一步的对照临床研究来阐明糖皮质激素诱导的神经精神症状的最佳治疗。

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