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首页> 外文期刊>Psychosomatics >Association of chronic liver disease with depression: a population-based study.
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Association of chronic liver disease with depression: a population-based study.

机译：慢性肝病与抑郁症的关联：一项基于人群的研究。

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Chronic liver diseases (CLD) have been associated with depression. Our aim was to assess the association of different types of CLD with depression in a population-based cohort.We examined data from National Health and Nutrition Examination Survey (NHANES 2005-2010). We included adult patients with chronic hepatitis C (CH-C), chronic hepatitis B (CH-B), alcohol-related liver disease (ALD), and nonalcoholic fatty liver disease (NAFLD). Patient Health Questionnaire (PHQ-9) survey was used as a depression screener. Univariate and multivariate analyses were performed to determine independent variables associated with each type of CLD and depression.The cohort included 10,231 NHANES participants. After multivariate analysis, CH-C was independently associated with age (OR = 1.05, 95% CI: 1.03-1.07), male gender (OR = 1.88, 95% CI: 1.19-2.97), African American race/ethnicity (OR = 2.50, 95% CI:1.50-4.18), smoking (OR = 6.20, 95% CI: 1.62-23.68), injection drug use (OR = 52.86, 95% CI:32.87-85.03), and depression (OR = 2.87, 95% CI: 1.78-4.62). CH-B was independently associated with being non-Caucasian (for African Americans OR = 5.09, 95% CI: 2.41-10.76, for other races OR = 4.74, 95% CI: 2.32-9.70). ALD was independently associated with younger age (OR = 0.98, 95% CI: 0.96-0.99), male gender (OR = 1.53, 95% CI: 1.19-1.95), Mexican American race/ethnicity (OR = 2.63, 95% CI: 1.87-3.69), and moderate to heavy smoking (OR = 2.08, 95% CI: 1.46-2.96). Finally, presence of insulin resistance [OR = 2.65 95% CI: 1.98-3.55], diabetes [OR = 1.54 95% CI: 1.11-2.13], and Mexican American race/ethnicity [OR = 2.03(1.35-3.06)], were predictive of NAFLD.Although depression has been suspected to be associated with a number of CLD, this association remains strong only for CH-C.
机译：慢性肝病（CLD）与抑郁症有关。我们的目的是评估以人群为基础的队列中不同类型的CLD与抑郁症的相关性。我们检查了国家健康和营养检查调查（NHANES 2005-2010）的数据。我们纳入了患有慢性丙型肝炎（CH-C），慢性乙型肝炎（CH-B），酒精相关性肝病（ALD）和非酒精性脂肪肝（NAFLD）的成年患者。患者健康问卷（PHQ-9）调查被用作抑郁筛查工具。进行单因素和多因素分析以确定与每种类型的CLD和抑郁相关的自变量。该队列包括10,231名NHANES参与者。经过多变量分析后，CH-C与年龄（OR = 1.05，95％CI：1.03-1.07），男性（OR = 1.88，95％CI：1.19-2.97），非裔美国人种族/民族（OR = 2.50、95％CI：1.50-4.18），吸烟（OR = 6.20、95％CI：1.62-23.68），注射吸毒（OR = 52.86、95％CI：32.87-85.03）和抑郁症（OR = 2.87， 95％CI：1.78-4.62）。 CH-B与非高加索人独立相关（非裔美国人OR = 5.09，95％CI：2.41-10.76，其他种族OR = 4.74，95％CI：2.32-9.70）。 ALD与年龄较小（OR = 0.98，95％CI：0.96-0.99），男性（OR = 1.53，95％CI：1.19-1.95），墨西哥裔种族/民族（OR = 2.63，95％CI）独立相关：1.87-3.69），以及中度至重度吸烟（OR = 2.08，95％CI：1.46-2.96）。最后，存在胰岛素抵抗[OR = 2.65 95％CI：1.98-3.55]，糖尿病[OR = 1.54 95％CI：1.11-2.13]和墨西哥裔/种族[OR = 2.03（1.35-3.06）]，尽管怀疑抑郁症与许多CLD有关，但这种关联仅对CH-C仍然很强。

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