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Fulminant hepatic failure in the context of reinstituting valproate use

机译:重新使用丙戊酸盐的情况下发生剧烈肝衰竭

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摘要

Valproate is an effective treatment for bipolar disorder and epilepsy. Valproate has also been frequently associated with self-limited asymptomatic transami-nase elevations or hyperammonemia or both. Life-threatening cases of liver failure, though, are much less common (1-3 per 100,000 person-years). We report a case of fulminant hepatic failure associated with valproate reintroduction in a patient with previous valproate exposure.
机译:丙戊酸是治疗躁郁症和癫痫的有效方法。丙戊酸还经常与自我限制的无症状转氨酶升高或高氨血症或两者兼有。但是,威胁生命的肝衰竭病例要少得多(每100,000人年1-3例)。我们报告了先前有丙戊酸盐暴露的患者发生丙戊酸盐再引入相关的暴发性肝功能衰竭病例。

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