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Critical Analysis of the Efficacy of Meditation Therapies for Acute and Subacute Phase Treatment of Depressive Disorders: A Systematic Review

机译:抑郁症的急性和亚急性期治疗的冥想疗法的疗效的关键分析:系统评价。

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Background: Recently, the application of meditative practices to the treatment of depressive disorders has met with increasing clinical and scientific interest, owing to a lower side-effect burden, potential reduction of polypharmacy, and theoretical considerations that such interventions may target some of the cognitive roots of depression. Objective: We aimed to determine the state of the evidence supporting this application. Methods: Randomized controlled trials of techniques meeting the Agency for Healthcare Research and Quality definition of meditation, for participants having clinically diagnosed depressive disorders, not currently in remission, were selected. Meditation therapies were separated into praxis (i.e., how they were applied) components, and trial outcomes were reviewed. Results: 18 studies meeting the inclusion criteria were identified, encompassing 7 distinct techniques and 1173 patients. Mindfulness-Based Cognitive Therapy comprised the largest proportion of studies. Studies including patients having acute major depressive episodes (n = 10 studies), and those with residual subacute clinical symptoms despite initial treatment (n = 8), demonstrated moderate to large reductions in depression symptoms within the group, and relative to control groups. There was significant heterogeneity of techniques and trial designs. Conclusions: A substantial body of evidence indicates that meditation therapies may have salutary (fleets on patients having clinical depressive disorders during the acute and subacute phases of treatment. Owing to methodologic deficiencies and trial heterogeneity, large-scale, randomized controlled trials with well-described comparator interventions and measures of expectation are needed to clarify the role of meditation in the depression treatment armamentarium.
机译:背景:最近,由于副作用减轻,多药店的潜在减少以及理论上的考虑,这类干预措施可能针对某些认知障碍,因此将冥想方法应用于抑郁症的治疗已引起越来越多的临床和科学兴趣。抑郁症的根源。目的:我们旨在确定支持该申请的证据状态。方法:针对临床诊断为抑郁症但目前尚未缓解的参与者,选择符合医疗保健研究机构和冥想质量定义的技术的随机对照试验。冥想疗法分为实践部分(即应用方式),并审查了试验结果。结果:确定了18项符合纳入标准的研究,包括7种不同的技术和1173例患者。基于正念的认知疗法占研究的最大比例。包括急性重度抑郁发作的患者(n = 10项研究)以及尽管经过初始治疗仍具有亚急性临床症状的患者(n = 8)的研究表明,与对照组相比,抑郁症状在中度至大范围减轻。技术和试验设计存在很大的异质性。结论:大量证据表明,冥想疗法可能具有有益的作用(在急性和亚急性治疗阶段,对于患有临床抑郁症的患者可能会产生敬意。由于方法学上的缺陷和试验的异质性,大规模,随机对照试验具有良好的描述需要比较者的干预措施和预期措施,以阐明冥想在抑郁症治疗武器库中的作用。

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