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首页> 外文期刊>Ultrasonics sonochemistry >The use of a microbubble agent to enhance rabbit liver destruction using high intensity focused ultrasound
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The use of a microbubble agent to enhance rabbit liver destruction using high intensity focused ultrasound

机译：使用微泡剂通过高强度聚焦超声促进兔肝破坏

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摘要

Liver tissues in New Zealand rabbits were ablated using high intensity focused ultrasound (HIFU, 14300 W/cm(2), 1.0 MHz). The animals were intravenously administered 0.2 ml of microbubble agent in the experimental (n = 20) group and an isovolumetric normal saline solution in the control (n = 27) group before HIFU treatment which was performed as a linear scan. In both groups, the preselected tissue volumes were destroyed without harming the overlying tissues. Necrosis rate (NR, cm(3)/s) was used to reflect the ablation efficiency, which was the tissue volume of occurring coagulative necrosis per 1 s HIFU exposure. NR was improved in the experimental group (0.0570 +/- 0.0433 vs 0.0120 +/- 0.0122, P = 0.0002). Pathological studies confirmed that there were no residual intact targets within the exposed volume. These findings suggested that the introduction of the microbubble agent enhanced HIFU liver destruction. (c) 2005 Elsevier B.V. All rights reserved.
机译：使用高强度聚焦超声（HIFU，14300 W / cm（2），1.0 MHz）消融新西兰兔的肝组织。在进行线性扫描的HIFU治疗之前，在实验组（n = 20）中为动物静脉注射0.2 ml的微泡剂，在对照组（n = 27）中为等体积生理盐水。在两组中，预选的组织体积均被破坏，而不会损害其上覆的组织。坏死率（NR，cm（3）/ s）用于反映消融效率，即每1 s HIFU暴露发生的凝固性坏死的组织体积。实验组的NR改善（0.0570 +/- 0.0433与0.0120 +/- 0.0122，P = 0.0002）。病理研究证实，暴露的体积内没有残留的完整靶标。这些发现表明，微泡剂的引入增强了HIFU肝破坏。 （c）2005 Elsevier B.V.保留所有权利。

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