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Coronary plaque volume and composition assessed by computed tomography angiography in patients with late-onset major depression

机译：通过计算机断层摄影血管造影评估晚期迟发性重度抑郁患者的冠状动脉斑块体积和成分

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Background: Depression is a stronger predictor for the onset of or death from clinical coronary artery disease than traditional cardiovascular risk factors. The association between depression and coronary artery disease has previously been investigated in non-contrast enhanced computed tomography studies with conflicting results. The aim of this study was to further elucidate the depression-coronary artery disease relation by use of coronary computed tomography angiography. Methods: The calcified and noncalcified coronary plaque volumes were determined by semiautomatic volumetric quantification in 28 patients with late-onset major depression and 27 controls. The calcified plaque proportion, i.e., the calcified plaque volume divided by the total plaque volume, was used to assess the plaque composition. Results: There was no statistically significant difference in the total (. p = 0.48), calcified (. p = 0.15), and noncalcified (. p = 0.62) plaque volume between patients and controls, and the total plaque volume did not predict depression, odds ratio = 1.001 [95% confidence interval: 0.999-1.003; p = 0.23]. However, the calcified plaque proportion was twice as high in patients compared with controls (14% vs. 7%, p = 0.044). Correspondingly, having depression was associated with an increased calcified plaque proportion of 11.3 [95% confidence interval: 2.63-20.1; p = 0.012] percentage points after adjustment for demographics and cardiovascular risk factors. Conclusion: The proportion of the total coronary plaque volume that was calcified was significantly higher in patients with late-onset major depression than in controls, indicating a difference in plaque composition.
机译：背景：与传统的心血管危险因素相比，抑郁是临床冠状动脉疾病发作或死亡的更强有力的预测指标。先前已经在非对比增强计算机断层扫描研究中对抑郁症和冠状动脉疾病之间的关联进行了研究，但结果相互矛盾。这项研究的目的是通过使用冠状动脉计算机断层扫描血管造影进一步阐明抑郁症与冠状动脉疾病的关系。方法：采用半自动体积定量法对28例迟发性重度抑郁症患者和27例对照者的钙化和非钙化冠状动脉斑块体积进行了测定。使用钙化的斑块比例，即钙化的斑块体积除以总斑块体积，来评估斑块组成。结果：患者和对照组之间的斑块总量（。p = 0.48），钙化斑块（。p = 0.15）和未钙化斑块（。p = 0.62）在统计学上无显着差异，并且总斑块量不能预测抑郁症的发生。 ，优势比= 1.001 [95％置信区间：0.999-1.003; p ＝ 0.23]。但是，患者的钙化斑块比例是对照组的两倍（14％比7％，p = 0.044）。相应地，患有抑郁症与钙化斑块比例增加11.3有关[95％置信区间：2.63-20.1;调整了人口统计学和心血管危险因素后，p = 0.012]个百分点。结论：晚期严重抑郁症患者的钙化总冠状动脉斑块比例明显高于对照组，表明斑块组成有所不同。

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