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Serotonin syndrome in a patient on tramadol, bupropion, trazodone, and oxycodone

机译:曲马多,安非他酮,曲唑酮和羟考酮患者的5-羟色胺综合征

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摘要

Because of their known serotonergic activity, anti-depressants are well recognized in the precipitation of serotonin syndrome (SS). Serotonergic effects of the analgesic tramadol, however, are not as well understood. Several reports detail cases of SS caused by tramadol overdose. To our knowledge, only one case report has ever raised the possibility of SS in a patient on a therapeutic dose of tramadol alone. Other reports demonstrate the development of SS on nonexcessive doses of tramadol due to interactions with other drugs, usually serotonin-specific reuptake inhibitors. Here, we describe a case of SS in a patient on a routine dose of tramadol, combined with several nonserotonin-specific reuptake inhibitor medications: bupropion, trazodone, and oxycodone.
机译:由于其已知的血清素能活性,抗抑郁药在5-羟色胺综合征(SS)的沉淀中广为人知。然而,止痛曲马多的血清素能作用还没有被很好地理解。一些报告详细说明了由曲马多过量引起的SS病例。据我们所知,仅一例病例报告曾提出仅使用曲马多治疗剂量的患者出现SS的可能性。其他报道表明,由于与其他药物(通常是5-羟色胺特异性再摄取抑制剂)的相互作用,在非过量的曲马多上出现了SS。在这里,我们描述了在常规剂量的曲马多中,结合几种非血清素特异性再摄取抑制剂药物:安非他酮,曲唑酮和羟考酮的SS患者。

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