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Safety of trazodone as a sleep agent for inpatients.

机译:曲唑酮作为住院药物的安全性。

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摘要

Trazodone, an atypical antidepressant with relatively low anticholinergic and cardiac conduction effects, offers useful augmentation to classic antidepressant drugs, notably selective serotonin reuptake inhibitors. One rare but serious side effect of the drug is priapism, the urological emergency in which the cavernosa of the penis become painfully engorged in the absence of sexual stimulation. The authors present what appears to be the first published case of priapism requiring urologic intervention after a single 100-mg dose of trazodone. In addition to a discussion of the history and physiology of trazodone and priapism, the authors present a profile of patients who present a safety risk in treatment.
机译:曲唑酮是一种具有相对较低的抗胆碱能和心脏传导作用的非典型抗抑郁药,可为经典抗抑郁药(尤其是选择性5-羟色胺再摄取抑制剂)提供有用的补充。该药的一种罕见但严重的副作用是阴茎异常勃起,这是一种泌尿外科急症,在没有性刺激的情况下,阴茎的海绵体疼痛性充血。作者介绍了似乎是首次公开发表的阴茎异常勃勃的病例,单剂量100毫克曲唑酮后需要泌尿科介入治疗。除了讨论曲唑酮和阴茎异常勃起的病史和生理学外,作者还介绍了存在治疗安全风险的患者概况。

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