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首页> 外文期刊>Ultrasound in Medicine and Biology >Cardiovascular assessment of fetal mice by in utero echocardiography.
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Cardiovascular assessment of fetal mice by in utero echocardiography.

机译：宫腔超声心动图对胎儿小鼠的心血管评估。

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摘要

To establish a developmental profile of fetal mouse cardiovascular parameters, we analyzed a large body of ultrasound measurements obtained by in utero echocardiography of C57BL/6J fetal mice from embryonic day 12.5 to 19.5 (term). Measurements were obtained using two-dimensional (2D), spectral Doppler and M-mode imaging with standard clinical cardiac ultrasound imaging planes. As these studies were conducted as part of a large scale mouse mutagenesis screen, stringent filtering criteria were used to eliminate potentially abnormal fetuses. Our analysis showed heart rate increased from 190 to 245 beats per minute as the mouse fetus grew from 8 mm at embryonic day 12.5 to 18.7 mm at term. This was accompanied by increases in peak outflow velocity, E-wave, E/A ratio and ventricular dimensions. In contrast, the A-wave, myocardial performance index and isovolemic contraction time decreased gradually. Systolic function remained remarkably stable at 80% ejection fraction. Analysis of intra- and interobserver variabilities showed these parameters were reproducible, with most comparing favorably to clinical ultrasound measurements in human fetuses. A comprehensive database was generated comprising 23 echocardiographic parameters delineating fetal mouse cardiovascular function from embryonic day 12.5 to term. This database can serve as a standard for evaluating cardiovascular pathophysiology in genetically altered and mutant mouse models.
机译：为了建立胎儿小鼠心血管参数的发育概况，我们分析了从C12.5BL / 6J胎儿小鼠胚胎第12.5天到19.5天（足月）通过宫腔超声心动图获得的大量超声测量结果。使用二维（2D），频谱多普勒和M模式成像以及标准的临床心脏超声成像平面获得测量结果。由于这些研究是作为大规模小鼠诱变筛选的一部分进行的，因此采用了严格的过滤标准来消除潜在的异常胎儿。我们的分析显示，随着小鼠胎儿从胚胎期的8毫米长增长到足月的12.5到18.7毫米，心率从每分钟190搏动增加到245搏动。这伴随着峰值流出速度，E波，E / A比和心室尺寸的增加。相反，A波，心肌功能指数和等容收缩时间逐渐减少。收缩功能在射血分数80％时保持显着稳定。观察者之间和观察者之间的变异性分析表明，这些参数是可重现的，与人类胎儿的临床超声测量结果相比最有利。生成了包含23个超声心动图参数的综合数据库，这些参数描述了从胚胎12.5天到足月胎鼠的心血管功能。该数据库可以作为评估基因改变和突变小鼠模型中心血管病理生理的标准。

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